Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | FAM84A | family with sequence similarity 84, member A (292 aa) | ||||||||||||
Predicted Functional Partners:
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 | CCDC14 | coiled-coil domain containing 14 (912 aa) |
 |
0.506 | ||||||||||
 | DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] (740 aa) |
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0.499 | ||||||||||
 | FAM3A | family with sequence similarity 3, member A; May act as a defensin against invading fungal microorganisms (230 aa) |
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0.472 | ||||||||||
 | FBXL4 | F-box and leucine-rich repeat protein 4 (621 aa) |
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0.471 | ||||||||||
 | ALS2CL | ALS2 C-terminal like (953 aa) |
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0.459 | ||||||||||
 | NBAS | neuroblastoma amplified sequence (2371 aa) |
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0.452 | ||||||||||
 | FAM49A | family with sequence similarity 49, member A (323 aa) |
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0.426 | ||||||||||
 | ANKRD22 | ankyrin repeat domain 22 (191 aa) |
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0.407 | ||||||||||
 | RNLS | renalase, FAD-dependent amine oxidase; Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes [...] (342 aa) |
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0.407 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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