Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | CCDC74A | coiled-coil domain containing 74A (378 aa) | ||||||||||||
Predicted Functional Partners:
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 | GINM1 | glycoprotein integral membrane 1 (330 aa) |
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0.704 | ||||||||||
 | ZNF544 | zinc finger protein 544; May be involved in transcriptional regulation (715 aa) |
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0.643 | ||||||||||
 | KCTD4 | potassium channel tetramerisation domain containing 4 (259 aa) |
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0.631 | ||||||||||
 | PANX2 | pannexin 2; Structural component of the gap junctions and the hemichannels (By similarity) (677 aa) |
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0.590 | ||||||||||
 | CYSTM1 | cysteine-rich transmembrane module containing 1 (97 aa) |
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0.539 | ||||||||||
 | MFSD2A | major facilitator superfamily domain containing 2A; Plays a role in thermogenesis via beta-adrenergic signaling pathway. May be the main plasma membrane tunicamycin transporter (543 aa) |
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0.482 | ||||||||||
 | RASEF | RAS and EF-hand domain containing; Binds predominantly GDP, and also GTP (740 aa) |
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0.450 | ||||||||||
 | C7orf55 | chromosome 7 open reading frame 55 (113 aa) |
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0.426 | ||||||||||
 | FTMT | ferritin mitochondrial; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (242 aa) |
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0.414 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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