CLDN1 protein (Homo sapiens) - STRING network view

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CLDN1

claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells (211 aa)

Predicted Functional Partners:

TJP1

0.979

TJP2

0.977

TJP3

0.976

INADL

0.959

F11R

0.954

MPDZ

0.943

CD81

0.926

MMP14

0.919

CLDN5

0.914

PVRL3

0.909

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD81	CLDN1	ENSP00000263645	ENSP00000295522	CD81 molecule; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	0.926
CLDN1	CD81	ENSP00000295522	ENSP00000263645	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	CD81 molecule; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV	0.926
CLDN1	CLDN5	ENSP00000295522	ENSP00000384554	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)	0.914
CLDN1	F11R	ENSP00000295522	ENSP00000289779	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	F11 receptor; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus	0.954
CLDN1	INADL	ENSP00000295522	ENSP00000360200	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	InaD-like (Drosophila)	0.959
CLDN1	MMP14	ENSP00000295522	ENSP00000308208	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	matrix metallopeptidase 14 (membrane-inserted); Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15	0.919
CLDN1	MPDZ	ENSP00000295522	ENSP00000370410	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	multiple PDZ domain protein	0.943
CLDN1	PVRL3	ENSP00000295522	ENSP00000418070	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	poliovirus receptor-related 3; Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. P [...]	0.909
CLDN1	TJP1	ENSP00000295522	ENSP00000281537	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells	0.979
CLDN1	TJP2	ENSP00000295522	ENSP00000438262	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	tight junction protein 2	0.977
CLDN1	TJP3	ENSP00000295522	ENSP00000262968	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	tight junction protein 3	0.976
CLDN5	CLDN1	ENSP00000384554	ENSP00000295522	claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	0.914
CLDN5	F11R	ENSP00000384554	ENSP00000289779	claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)	F11 receptor; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus	0.418
CLDN5	INADL	ENSP00000384554	ENSP00000360200	claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)	InaD-like (Drosophila)	0.865
CLDN5	MPDZ	ENSP00000384554	ENSP00000370410	claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)	multiple PDZ domain protein	0.990
CLDN5	TJP1	ENSP00000384554	ENSP00000281537	claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)	tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells	0.983
CLDN5	TJP2	ENSP00000384554	ENSP00000438262	claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)	tight junction protein 2	0.950
CLDN5	TJP3	ENSP00000384554	ENSP00000262968	claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)	tight junction protein 3	0.928
F11R	CLDN1	ENSP00000289779	ENSP00000295522	F11 receptor; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus	claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells	0.954
F11R	CLDN5	ENSP00000289779	ENSP00000384554	F11 receptor; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus	claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)	0.418

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