FAM19A4 protein (Homo sapiens) - STRING network view

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Score

FAM19A4

family with sequence similarity 19 (chemokine (C-C motif)-like), member A4 (140 aa)

Predicted Functional Partners:

PHACTR3

0.564

PRDM14

0.506

LFNG

0.479

PQLC2

0.470

NKX2-8

0.426

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM19A4	LFNG	ENSP00000295569	ENSP00000222725	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity)	0.479
FAM19A4	NKX2-8	ENSP00000295569	ENSP00000258829	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	NK2 homeobox 8	0.426
FAM19A4	PHACTR3	ENSP00000295569	ENSP00000360054	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	phosphatase and actin regulator 3	0.564
FAM19A4	PQLC2	ENSP00000295569	ENSP00000364295	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	PQ loop repeat containing 2; Lysosomal lysine/arginine transporter that specifically mediates the export of lysine and arginine from lysosomes	0.470
FAM19A4	PRDM14	ENSP00000295569	ENSP00000276594	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	PR domain containing 14; Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels- the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5’-GGT [...]	0.506
LFNG	FAM19A4	ENSP00000222725	ENSP00000295569	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity)	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	0.479
NKX2-8	FAM19A4	ENSP00000258829	ENSP00000295569	NK2 homeobox 8	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	0.426
PHACTR3	FAM19A4	ENSP00000360054	ENSP00000295569	phosphatase and actin regulator 3	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	0.564
PQLC2	FAM19A4	ENSP00000364295	ENSP00000295569	PQ loop repeat containing 2; Lysosomal lysine/arginine transporter that specifically mediates the export of lysine and arginine from lysosomes	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	0.470
PRDM14	FAM19A4	ENSP00000276594	ENSP00000295569	PR domain containing 14; Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels- the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5’-GGT [...]	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	0.506

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