node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDX41 | GAD2 | ENSP00000422753 | ENSP00000259271 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | 0.450 |
DDX41 | INS | ENSP00000422753 | ENSP00000250971 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.913 |
DDX41 | PTPRN | ENSP00000422753 | ENSP00000295718 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | 0.855 |
GAD2 | DDX41 | ENSP00000259271 | ENSP00000422753 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing | 0.450 |
GAD2 | INS | ENSP00000259271 | ENSP00000250971 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.960 |
GAD2 | LAD1 | ENSP00000259271 | ENSP00000375829 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | ladinin 1; Anchoring filament protein which is a component of the basement membrane zone (By similarity) | 0.813 |
GAD2 | PTPRN | ENSP00000259271 | ENSP00000295718 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | 0.919 |
INS | DDX41 | ENSP00000250971 | ENSP00000422753 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing | 0.913 |
INS | GAD2 | ENSP00000250971 | ENSP00000259271 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | 0.960 |
INS | INSM1 | ENSP00000250971 | ENSP00000312631 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | insulinoma-associated 1; May be associated with the transformation of neuroendocrine cells | 0.851 |
INS | LAD1 | ENSP00000250971 | ENSP00000375829 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | ladinin 1; Anchoring filament protein which is a component of the basement membrane zone (By similarity) | 0.724 |
INS | PTPRN | ENSP00000250971 | ENSP00000295718 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | 0.813 |
INSM1 | INS | ENSP00000312631 | ENSP00000250971 | insulinoma-associated 1; May be associated with the transformation of neuroendocrine cells | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.851 |
INSM1 | MAPK8IP1 | ENSP00000312631 | ENSP00000241014 | insulinoma-associated 1; May be associated with the transformation of neuroendocrine cells | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | 0.815 |
INSM1 | MAPK8IP2 | ENSP00000312631 | ENSP00000330572 | insulinoma-associated 1; May be associated with the transformation of neuroendocrine cells | mitogen-activated protein kinase 8 interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) | 0.720 |
INSM1 | PTPRN | ENSP00000312631 | ENSP00000295718 | insulinoma-associated 1; May be associated with the transformation of neuroendocrine cells | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | 0.876 |
LAD1 | GAD2 | ENSP00000375829 | ENSP00000259271 | ladinin 1; Anchoring filament protein which is a component of the basement membrane zone (By similarity) | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | 0.813 |
LAD1 | INS | ENSP00000375829 | ENSP00000250971 | ladinin 1; Anchoring filament protein which is a component of the basement membrane zone (By similarity) | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.724 |
LAD1 | PTPRN | ENSP00000375829 | ENSP00000295718 | ladinin 1; Anchoring filament protein which is a component of the basement membrane zone (By similarity) | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | 0.812 |
MAPK8IP1 | INSM1 | ENSP00000241014 | ENSP00000312631 | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | insulinoma-associated 1; May be associated with the transformation of neuroendocrine cells | 0.815 |