CRYBA2 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

CRYBA2

crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens (197 aa)

Predicted Functional Partners:

CRYAA

0.685

CRYBB3

0.603

CRYBB2

0.603

CRYBB1

0.602

IGDCC3

0.552

CRYAB

0.509

CALCOCO1

0.506

C21orf62

0.506

CRYM

0.481

ESYT3

0.471

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C21orf62	CRYBA2	ENSP00000418511	ENSP00000295728	chromosome 21 open reading frame 62	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	0.506
CALCOCO1	CRYBA2	ENSP00000449960	ENSP00000295728	calcium binding and coiled-coil domain 1; Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its inte [...]	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	0.506
CRYAA	CRYAB	ENSP00000291554	ENSP00000227251	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	0.701
CRYAA	CRYBA2	ENSP00000291554	ENSP00000295728	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	0.685
CRYAA	CRYBB1	ENSP00000291554	ENSP00000215939	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, beta B1; Crystallins are the dominant structural components of the vertebrate eye lens	0.774
CRYAA	CRYBB2	ENSP00000291554	ENSP00000381273	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, beta B2; Crystallins are the dominant structural components of the vertebrate eye lens	0.980
CRYAA	CRYBB3	ENSP00000291554	ENSP00000215855	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, beta B3; Crystallins are the dominant structural components of the vertebrate eye lens	0.896
CRYAB	CRYAA	ENSP00000227251	ENSP00000291554	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	0.701
CRYAB	CRYBA2	ENSP00000227251	ENSP00000295728	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	0.509
CRYAB	CRYBB1	ENSP00000227251	ENSP00000215939	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, beta B1; Crystallins are the dominant structural components of the vertebrate eye lens	0.700
CRYAB	CRYBB2	ENSP00000227251	ENSP00000381273	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, beta B2; Crystallins are the dominant structural components of the vertebrate eye lens	0.888
CRYAB	CRYBB3	ENSP00000227251	ENSP00000215855	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, beta B3; Crystallins are the dominant structural components of the vertebrate eye lens	0.750
CRYBA2	C21orf62	ENSP00000295728	ENSP00000418511	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	chromosome 21 open reading frame 62	0.506
CRYBA2	CALCOCO1	ENSP00000295728	ENSP00000449960	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	calcium binding and coiled-coil domain 1; Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its inte [...]	0.506
CRYBA2	CRYAA	ENSP00000295728	ENSP00000291554	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	0.685
CRYBA2	CRYAB	ENSP00000295728	ENSP00000227251	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	0.509
CRYBA2	CRYBB1	ENSP00000295728	ENSP00000215939	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	crystallin, beta B1; Crystallins are the dominant structural components of the vertebrate eye lens	0.602
CRYBA2	CRYBB2	ENSP00000295728	ENSP00000381273	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	crystallin, beta B2; Crystallins are the dominant structural components of the vertebrate eye lens	0.603
CRYBA2	CRYBB3	ENSP00000295728	ENSP00000215855	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	crystallin, beta B3; Crystallins are the dominant structural components of the vertebrate eye lens	0.603
CRYBA2	CRYM	ENSP00000295728	ENSP00000219599	crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens	crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors	0.481

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