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STRINGSTRING
IL9 IL9 CHI3L2 CHI3L2 IL21R IL21R IL13RA1 IL13RA1 CHIA CHIA CCL17 CCL17 RETNLB RETNLB STAT6 STAT6 GREM2 GREM2 ARG1 ARG1 MRC1 MRC1
"RETNLB" - resistin like beta in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RETNLBresistin like beta; Probable hormone (111 aa)    
Predicted Functional Partners:
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced; Carries out a dual function- signal transduction and activation of transcription. Involved in interleukin-4 signalling (847 aa)
          score_image score_image   0.938
ARG1
arginase, liver (322 aa)
            score_image   0.561
IL21R
interleukin 21 receptor; This is a receptor for interleukin-21 (538 aa)
            score_image   0.561
CCL17
chemokine (C-C motif) ligand 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 (94 aa)
            score_image   0.525
IL9
interleukin 9; Supports IL-2 independent and IL-4 independent growth of helper T-cells (144 aa)
            score_image   0.496
CHI3L2
chitinase 3-like 2; Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity (390 aa)
            score_image   0.489
IL13RA1
interleukin 13 receptor, alpha 1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity (427 aa)
            score_image   0.483
MRC1
mannose receptor, C type 1; Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens (1456 aa)
            score_image   0.439
CHIA
chitinase, acidic (476 aa)
            score_image   0.432
GREM2
gremlin 2; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells (By similarity) (168 aa)
            score_image   0.408
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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