node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD247 | CD3D | ENSP00000354782 | ENSP00000300692 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.985 |
CD247 | CD3E | ENSP00000354782 | ENSP00000354566 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.995 |
CD247 | CD4 | ENSP00000354782 | ENSP00000011653 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.949 |
CD247 | CD8A | ENSP00000354782 | ENSP00000283635 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.968 |
CD247 | SYK | ENSP00000354782 | ENSP00000364898 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.944 |
CD247 | TRAT1 | ENSP00000354782 | ENSP00000295756 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | 0.990 |
CD247 | ZAP70 | ENSP00000354782 | ENSP00000264972 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...] | 0.999 |
CD3D | CD247 | ENSP00000300692 | ENSP00000354782 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | 0.985 |
CD3D | CD3E | ENSP00000300692 | ENSP00000354566 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.999 |
CD3D | CD4 | ENSP00000300692 | ENSP00000011653 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.943 |
CD3D | CD8A | ENSP00000300692 | ENSP00000283635 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.975 |
CD3D | SYK | ENSP00000300692 | ENSP00000364898 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.912 |
CD3D | TRAT1 | ENSP00000300692 | ENSP00000295756 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | 0.906 |
CD3D | ZAP70 | ENSP00000300692 | ENSP00000264972 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...] | 0.926 |
CD3E | CD247 | ENSP00000354566 | ENSP00000354782 | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | 0.995 |
CD3E | CD3D | ENSP00000354566 | ENSP00000300692 | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.999 |
CD3E | CD4 | ENSP00000354566 | ENSP00000011653 | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.937 |
CD3E | CD8A | ENSP00000354566 | ENSP00000283635 | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.942 |
CD3E | PIK3R1 | ENSP00000354566 | ENSP00000274335 | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.932 |
CD3E | SYK | ENSP00000354566 | ENSP00000364898 | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.984 |