node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGR1 | GLB1L | ENSP00000239938 | ENSP00000295759 | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | 0.673 |
EGR1 | MEF2A | ENSP00000239938 | ENSP00000346389 | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | myocyte enhancer factor 2A | 0.442 |
EGR1 | MEF2C | ENSP00000239938 | ENSP00000340874 | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | 0.401 |
EGR3 | GLB1L | ENSP00000318057 | ENSP00000295759 | early growth response 3; Probable transcription factor involved in muscle spindle development | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | 0.615 |
FAM134A | GLB1L | ENSP00000395249 | ENSP00000295759 | family with sequence similarity 134, member A | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | 0.681 |
FAM134A | SLC23A3 | ENSP00000395249 | ENSP00000406546 | family with sequence similarity 134, member A | solute carrier family 23 (nucleobase transporters), member 3 | 0.520 |
GLB1L | EGR1 | ENSP00000295759 | ENSP00000239938 | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | 0.673 |
GLB1L | EGR3 | ENSP00000295759 | ENSP00000318057 | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | early growth response 3; Probable transcription factor involved in muscle spindle development | 0.615 |
GLB1L | FAM134A | ENSP00000295759 | ENSP00000395249 | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | family with sequence similarity 134, member A | 0.681 |
GLB1L | MEF2A | ENSP00000295759 | ENSP00000346389 | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | myocyte enhancer factor 2A | 0.632 |
GLB1L | MEF2B | ENSP00000295759 | ENSP00000162023 | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | myocyte enhancer factor 2B; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription | 0.612 |
GLB1L | MEF2C | ENSP00000295759 | ENSP00000340874 | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | 0.632 |
GLB1L | MEF2D | ENSP00000295759 | ENSP00000271555 | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | myocyte enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity) | 0.632 |
GLB1L | RUFY4 | ENSP00000295759 | ENSP00000363270 | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | RUN and FYVE domain containing 4 | 0.581 |
GLB1L | SLC23A3 | ENSP00000295759 | ENSP00000406546 | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | solute carrier family 23 (nucleobase transporters), member 3 | 0.549 |
GLB1L | TMED3 | ENSP00000295759 | ENSP00000299705 | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | transmembrane emp24 protein transport domain containing 3; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network | 0.468 |
MEF2A | EGR1 | ENSP00000346389 | ENSP00000239938 | myocyte enhancer factor 2A | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | 0.442 |
MEF2A | GLB1L | ENSP00000346389 | ENSP00000295759 | myocyte enhancer factor 2A | galactosidase, beta 1-like; Probable glycosyl hydrolase (Potential) | 0.632 |
MEF2A | MEF2C | ENSP00000346389 | ENSP00000340874 | myocyte enhancer factor 2A | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | 0.904 |
MEF2A | MEF2D | ENSP00000346389 | ENSP00000271555 | myocyte enhancer factor 2A | myocyte enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity) | 0.991 |