ABHD6 protein (Homo sapiens) - STRING network view

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ABHD6

abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity) (337 aa)

Predicted Functional Partners:

ABHD12

0.946

MGLL

0.775

FAAH

0.714

ABHD4

0.628

UBC

0.628

PHF7

0.621

ABHD11

0.588

ABHD12B

0.567

CNR1

0.544

MAPKAPK3

0.520

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD11	ABHD12	ENSP00000222800	ENSP00000365725	abhydrolase domain containing 11	abhydrolase domain containing 12	0.643
ABHD11	ABHD6	ENSP00000222800	ENSP00000295962	abhydrolase domain containing 11	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	0.588
ABHD11	FAAH	ENSP00000222800	ENSP00000243167	abhydrolase domain containing 11	fatty acid amide hydrolase; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates	0.464
ABHD11	MGLL	ENSP00000222800	ENSP00000265052	abhydrolase domain containing 11	monoglyceride lipase; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth	0.416
ABHD12	ABHD11	ENSP00000365725	ENSP00000222800	abhydrolase domain containing 12	abhydrolase domain containing 11	0.643
ABHD12	ABHD4	ENSP00000365725	ENSP00000414558	abhydrolase domain containing 12	abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...]	0.542
ABHD12	ABHD6	ENSP00000365725	ENSP00000295962	abhydrolase domain containing 12	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	0.946
ABHD12	CNR1	ENSP00000365725	ENSP00000358511	abhydrolase domain containing 12	cannabinoid receptor 1 (brain)	0.758
ABHD12	FAAH	ENSP00000365725	ENSP00000243167	abhydrolase domain containing 12	fatty acid amide hydrolase; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates	0.694
ABHD12	MGLL	ENSP00000365725	ENSP00000265052	abhydrolase domain containing 12	monoglyceride lipase; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth	0.805
ABHD12	UBC	ENSP00000365725	ENSP00000344818	abhydrolase domain containing 12	ubiquitin C	0.449
ABHD12B	ABHD6	ENSP00000336693	ENSP00000295962	abhydrolase domain containing 12B	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	0.567
ABHD4	ABHD12	ENSP00000414558	ENSP00000365725	abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...]	abhydrolase domain containing 12	0.542
ABHD4	ABHD6	ENSP00000414558	ENSP00000295962	abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...]	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	0.628
ABHD4	FAAH	ENSP00000414558	ENSP00000243167	abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...]	fatty acid amide hydrolase; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates	0.425
ABHD4	UBC	ENSP00000414558	ENSP00000344818	abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...]	ubiquitin C	0.752
ABHD6	ABHD11	ENSP00000295962	ENSP00000222800	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	abhydrolase domain containing 11	0.588
ABHD6	ABHD12	ENSP00000295962	ENSP00000365725	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	abhydrolase domain containing 12	0.946
ABHD6	ABHD12B	ENSP00000295962	ENSP00000336693	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	abhydrolase domain containing 12B	0.567
ABHD6	ABHD4	ENSP00000295962	ENSP00000414558	abhydrolase domain containing 6; Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity)	abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...]	0.628

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