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PI4K2A PI4K2A INPP4B INPP4B PIP5K1B PIP5K1B PIP5K1A PIP5K1A SBF2 SBF2 MTMR14 MTMR14 SYNJ2 SYNJ2 SYNJ1 SYNJ1 INPP4A INPP4A PI4K2B PI4K2B MTMR9 MTMR9
"MTMR14" - myotubularin related protein 14 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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white nodes:
second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
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cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
MTMR14myotubularin related protein 14 (650 aa)    
Predicted Functional Partners:
INPP4A
inositol polyphosphate-4-phosphatase, type I, 107kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate (977 aa)
          score_image score_image   0.906
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate (924 aa)
          score_image score_image   0.903
SYNJ1
synaptojanin 1; Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis (1612 aa)
          score_image score_image   0.903
SYNJ2
synaptojanin 2; Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis (1496 aa)
          score_image score_image   0.903
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha; Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity) (479 aa)
          score_image     0.900
PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organ [...] (562 aa)
          score_image     0.900
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta (540 aa)
          score_image     0.900
PI4K2B
phosphatidylinositol 4-kinase type 2 beta; Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the [...] (481 aa)
          score_image     0.900
MTMR9
myotubularin related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) (549 aa)
            score_image   0.706
SBF2
SET binding factor 2 (1849 aa)
            score_image   0.691
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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