node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
INPP4A | MTMR14 | ENSP00000074304 | ENSP00000296003 | inositol polyphosphate-4-phosphatase, type I, 107kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate | myotubularin related protein 14 | 0.906 |
INPP4A | PIP5K1A | ENSP00000074304 | ENSP00000357883 | inositol polyphosphate-4-phosphatase, type I, 107kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organ [...] | 0.900 |
INPP4A | PIP5K1B | ENSP00000074304 | ENSP00000265382 | inositol polyphosphate-4-phosphatase, type I, 107kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.900 |
INPP4A | SYNJ1 | ENSP00000074304 | ENSP00000409667 | inositol polyphosphate-4-phosphatase, type I, 107kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate | synaptojanin 1; Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis | 0.925 |
INPP4A | SYNJ2 | ENSP00000074304 | ENSP00000347792 | inositol polyphosphate-4-phosphatase, type I, 107kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate | synaptojanin 2; Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis | 0.936 |
INPP4B | MTMR14 | ENSP00000262992 | ENSP00000296003 | inositol polyphosphate-4-phosphatase, type II, 105kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | myotubularin related protein 14 | 0.903 |
INPP4B | PIP5K1A | ENSP00000262992 | ENSP00000357883 | inositol polyphosphate-4-phosphatase, type II, 105kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organ [...] | 0.900 |
INPP4B | PIP5K1B | ENSP00000262992 | ENSP00000265382 | inositol polyphosphate-4-phosphatase, type II, 105kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.900 |
INPP4B | SYNJ1 | ENSP00000262992 | ENSP00000409667 | inositol polyphosphate-4-phosphatase, type II, 105kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | synaptojanin 1; Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis | 0.913 |
INPP4B | SYNJ2 | ENSP00000262992 | ENSP00000347792 | inositol polyphosphate-4-phosphatase, type II, 105kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | synaptojanin 2; Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis | 0.922 |
MTMR14 | INPP4A | ENSP00000296003 | ENSP00000074304 | myotubularin related protein 14 | inositol polyphosphate-4-phosphatase, type I, 107kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate | 0.906 |
MTMR14 | INPP4B | ENSP00000296003 | ENSP00000262992 | myotubularin related protein 14 | inositol polyphosphate-4-phosphatase, type II, 105kDa; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | 0.903 |
MTMR14 | MTMR9 | ENSP00000296003 | ENSP00000221086 | myotubularin related protein 14 | myotubularin related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | 0.706 |
MTMR14 | PI4K2A | ENSP00000296003 | ENSP00000359665 | myotubularin related protein 14 | phosphatidylinositol 4-kinase type 2 alpha; Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity) | 0.900 |
MTMR14 | PI4K2B | ENSP00000296003 | ENSP00000264864 | myotubularin related protein 14 | phosphatidylinositol 4-kinase type 2 beta; Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the [...] | 0.900 |
MTMR14 | PIP5K1A | ENSP00000296003 | ENSP00000357883 | myotubularin related protein 14 | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organ [...] | 0.900 |
MTMR14 | PIP5K1B | ENSP00000296003 | ENSP00000265382 | myotubularin related protein 14 | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.900 |
MTMR14 | SBF2 | ENSP00000296003 | ENSP00000256190 | myotubularin related protein 14 | SET binding factor 2 | 0.691 |
MTMR14 | SYNJ1 | ENSP00000296003 | ENSP00000409667 | myotubularin related protein 14 | synaptojanin 1; Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis | 0.903 |
MTMR14 | SYNJ2 | ENSP00000296003 | ENSP00000347792 | myotubularin related protein 14 | synaptojanin 2; Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis | 0.903 |