SNRK protein (Homo sapiens) - STRING network view

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SNRK

SNF related kinase; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis (765 aa)

Predicted Functional Partners:

DUSP5

0.805

RPTOR

0.803

DUSP2

0.752

CAB39

0.743

HEY2

0.662

STK11

0.660

DUSP1

0.610

JUN

0.585

CD38

0.485

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAB39	DUSP5	ENSP00000258418	ENSP00000358596	calcium binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1	dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1	0.605
CAB39	HEY2	ENSP00000258418	ENSP00000357348	calcium binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1	hairy/enhancer-of-split related with YRPW motif 2; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5’- CACGTG-3’. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6	0.564
CAB39	SNRK	ENSP00000258418	ENSP00000296088	calcium binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1	SNF related kinase; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis	0.743
CAB39	STK11	ENSP00000258418	ENSP00000324856	calcium binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1	serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...]	0.999
CD38	DUSP5	ENSP00000226279	ENSP00000358596	CD38 molecule; Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system	dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1	0.472
CD38	SNRK	ENSP00000226279	ENSP00000296088	CD38 molecule; Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system	SNF related kinase; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis	0.485
DUSP1	DUSP2	ENSP00000239223	ENSP00000288943	dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity)	dual specificity phosphatase 2; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2	0.903
DUSP1	JUN	ENSP00000239223	ENSP00000360266	dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity)	jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation	0.988
DUSP1	SNRK	ENSP00000239223	ENSP00000296088	dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity)	SNF related kinase; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis	0.610
DUSP2	DUSP1	ENSP00000288943	ENSP00000239223	dual specificity phosphatase 2; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2	dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity)	0.903
DUSP2	SNRK	ENSP00000288943	ENSP00000296088	dual specificity phosphatase 2; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2	SNF related kinase; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis	0.752
DUSP5	CAB39	ENSP00000358596	ENSP00000258418	dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1	calcium binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1	0.605
DUSP5	CD38	ENSP00000358596	ENSP00000226279	dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1	CD38 molecule; Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system	0.472
DUSP5	HEY2	ENSP00000358596	ENSP00000357348	dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1	hairy/enhancer-of-split related with YRPW motif 2; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5’- CACGTG-3’. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6	0.516
DUSP5	JUN	ENSP00000358596	ENSP00000360266	dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1	jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation	0.453
DUSP5	SNRK	ENSP00000358596	ENSP00000296088	dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1	SNF related kinase; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis	0.805
DUSP5	STK11	ENSP00000358596	ENSP00000324856	dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1	serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...]	0.457
HEY2	CAB39	ENSP00000357348	ENSP00000258418	hairy/enhancer-of-split related with YRPW motif 2; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5’- CACGTG-3’. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6	calcium binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1	0.564
HEY2	DUSP5	ENSP00000357348	ENSP00000358596	hairy/enhancer-of-split related with YRPW motif 2; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5’- CACGTG-3’. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6	dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1	0.516
HEY2	SNRK	ENSP00000357348	ENSP00000296088	hairy/enhancer-of-split related with YRPW motif 2; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5’- CACGTG-3’. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6	SNF related kinase; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis	0.662

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