node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACPP | GBA | ENSP00000323036 | ENSP00000314508 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | glucosidase, beta, acid | 0.745 |
ACPP | KLK2 | ENSP00000323036 | ENSP00000313581 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | kallikrein-related peptidase 2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin | 0.860 |
ACPP | KLK3 | ENSP00000323036 | ENSP00000314151 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | kallikrein-related peptidase 3; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum | 0.760 |
ACPP | KLKB1 | ENSP00000323036 | ENSP00000264690 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | kallikrein B, plasma (Fletcher factor) 1; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin | 0.759 |
ACPP | SLC45A3 | ENSP00000323036 | ENSP00000356113 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | solute carrier family 45, member 3 | 0.747 |
ACPP | STEAP2 | ENSP00000323036 | ENSP00000287908 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | STEAP family member 2, metalloreductase; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity) | 0.659 |
ACPP | STEAP4 | ENSP00000323036 | ENSP00000369419 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | STEAP family member 4; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation | 0.609 |
ACPP | SYT7 | ENSP00000323036 | ENSP00000263846 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | synaptotagmin VII; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity) | 0.608 |
ACPP | TGM4 | ENSP00000323036 | ENSP00000296125 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | transglutaminase 4 (prostate); Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract | 0.758 |
GBA | ACPP | ENSP00000314508 | ENSP00000323036 | glucosidase, beta, acid | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | 0.745 |
GBA | KLK2 | ENSP00000314508 | ENSP00000313581 | glucosidase, beta, acid | kallikrein-related peptidase 2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin | 0.684 |
GBA | KLK3 | ENSP00000314508 | ENSP00000314151 | glucosidase, beta, acid | kallikrein-related peptidase 3; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum | 0.563 |
GBA | KLKB1 | ENSP00000314508 | ENSP00000264690 | glucosidase, beta, acid | kallikrein B, plasma (Fletcher factor) 1; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin | 0.561 |
GBA | SLC45A3 | ENSP00000314508 | ENSP00000356113 | glucosidase, beta, acid | solute carrier family 45, member 3 | 0.518 |
GBA | STEAP2 | ENSP00000314508 | ENSP00000287908 | glucosidase, beta, acid | STEAP family member 2, metalloreductase; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity) | 0.420 |
GBA | TGM4 | ENSP00000314508 | ENSP00000296125 | glucosidase, beta, acid | transglutaminase 4 (prostate); Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract | 0.609 |
KLK2 | ACPP | ENSP00000313581 | ENSP00000323036 | kallikrein-related peptidase 2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | 0.860 |
KLK2 | GBA | ENSP00000313581 | ENSP00000314508 | kallikrein-related peptidase 2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin | glucosidase, beta, acid | 0.684 |
KLK2 | SLC45A3 | ENSP00000313581 | ENSP00000356113 | kallikrein-related peptidase 2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin | solute carrier family 45, member 3 | 0.689 |
KLK2 | STEAP2 | ENSP00000313581 | ENSP00000287908 | kallikrein-related peptidase 2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin | STEAP family member 2, metalloreductase; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity) | 0.608 |