| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDK9 | CLEC3B | ENSP00000362361 | ENSP00000296130 | cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytok [...] | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | 0.507 |
| CDK9 | NSD1 | ENSP00000362361 | ENSP00000395929 | cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytok [...] | nuclear receptor binding SET domain protein 1; Histone methyltransferase. Preferentially methylates ’Lys-36’ of histone H3 and ’Lys-20’ of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context | 0.898 |
| CLEC3B | CDK9 | ENSP00000296130 | ENSP00000362361 | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytok [...] | 0.507 |
| CLEC3B | HGF | ENSP00000296130 | ENSP00000222390 | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | hepatocyte growth factor (hepapoietin A; scatter factor) | 0.576 |
| CLEC3B | LYPD4 | ENSP00000296130 | ENSP00000328737 | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | LY6/PLAUR domain containing 4 | 0.475 |
| CLEC3B | NSD1 | ENSP00000296130 | ENSP00000395929 | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | nuclear receptor binding SET domain protein 1; Histone methyltransferase. Preferentially methylates ’Lys-36’ of histone H3 and ’Lys-20’ of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context | 0.472 |
| CLEC3B | PLAT | ENSP00000296130 | ENSP00000220809 | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | plasminogen activator, tissue | 0.587 |
| CLEC3B | PLG | ENSP00000296130 | ENSP00000308938 | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.955 |
| CLEC3B | PRSS23 | ENSP00000296130 | ENSP00000280258 | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | protease, serine, 23 | 0.508 |
| CLEC3B | PRSS35 | ENSP00000296130 | ENSP00000358714 | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | protease, serine, 35 | 0.493 |
| CLEC3B | RAD51 | ENSP00000296130 | ENSP00000372088 | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | 0.501 |
| CLEC3B | TRIM67 | ENSP00000296130 | ENSP00000355613 | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | tripartite motif containing 67 | 0.511 |
| HGF | CLEC3B | ENSP00000222390 | ENSP00000296130 | hepatocyte growth factor (hepapoietin A; scatter factor) | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | 0.576 |
| LYPD4 | CLEC3B | ENSP00000328737 | ENSP00000296130 | LY6/PLAUR domain containing 4 | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | 0.475 |
| LYPD4 | RAD51 | ENSP00000328737 | ENSP00000372088 | LY6/PLAUR domain containing 4 | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | 0.824 |
| LYPD4 | TRIM67 | ENSP00000328737 | ENSP00000355613 | LY6/PLAUR domain containing 4 | tripartite motif containing 67 | 0.508 |
| NSD1 | CDK9 | ENSP00000395929 | ENSP00000362361 | nuclear receptor binding SET domain protein 1; Histone methyltransferase. Preferentially methylates ’Lys-36’ of histone H3 and ’Lys-20’ of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context | cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytok [...] | 0.898 |
| NSD1 | CLEC3B | ENSP00000395929 | ENSP00000296130 | nuclear receptor binding SET domain protein 1; Histone methyltransferase. Preferentially methylates ’Lys-36’ of histone H3 and ’Lys-20’ of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | 0.472 |
| PLAT | CLEC3B | ENSP00000220809 | ENSP00000296130 | plasminogen activator, tissue | C-type lectin domain family 3, member B; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis | 0.587 |
| PLAT | PLG | ENSP00000220809 | ENSP00000308938 | plasminogen activator, tissue | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.963 |
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