node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CXCR6 | FYCO1 | ENSP00000304414 | ENSP00000296137 | chemokine (C-X-C motif) receptor 6; Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | 0.818 |
CXCR6 | RAB40AL | ENSP00000304414 | ENSP00000218249 | chemokine (C-X-C motif) receptor 6; Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1 | RAB40A, member RAS oncogene family-like; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) | 0.663 |
FOXK1 | FYCO1 | ENSP00000328720 | ENSP00000296137 | forkhead box K1; Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity) | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | 0.692 |
FYCO1 | CXCR6 | ENSP00000296137 | ENSP00000304414 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | chemokine (C-X-C motif) receptor 6; Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1 | 0.818 |
FYCO1 | FOXK1 | ENSP00000296137 | ENSP00000328720 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | forkhead box K1; Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity) | 0.692 |
FYCO1 | LMNA | ENSP00000296137 | ENSP00000357283 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | lamin A/C | 0.630 |
FYCO1 | MAP1LC3A | ENSP00000296137 | ENSP00000363970 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.837 |
FYCO1 | MAP1LC3B | ENSP00000296137 | ENSP00000268607 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.852 |
FYCO1 | RAB40AL | ENSP00000296137 | ENSP00000218249 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | RAB40A, member RAS oncogene family-like; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) | 0.860 |
FYCO1 | RAB7A | ENSP00000296137 | ENSP00000265062 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | 0.877 |
FYCO1 | SEC23B | ENSP00000296137 | ENSP00000262544 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | Sec23 homolog B (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity) | 0.692 |
FYCO1 | SEC24B | ENSP00000296137 | ENSP00000265175 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | SEC24 family, member B (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex | 0.969 |
FYCO1 | ZNF177 | ENSP00000296137 | ENSP00000415070 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | zinc finger protein 177; May be involved in transcriptional regulation | 0.662 |
LMNA | FYCO1 | ENSP00000357283 | ENSP00000296137 | lamin A/C | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | 0.630 |
MAP1LC3A | FYCO1 | ENSP00000363970 | ENSP00000296137 | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | 0.837 |
MAP1LC3A | RAB7A | ENSP00000363970 | ENSP00000265062 | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | 0.607 |
MAP1LC3B | FYCO1 | ENSP00000268607 | ENSP00000296137 | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | 0.852 |
MAP1LC3B | RAB7A | ENSP00000268607 | ENSP00000265062 | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | 0.641 |
RAB40AL | CXCR6 | ENSP00000218249 | ENSP00000304414 | RAB40A, member RAS oncogene family-like; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) | chemokine (C-X-C motif) receptor 6; Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1 | 0.663 |
RAB40AL | FYCO1 | ENSP00000218249 | ENSP00000296137 | RAB40A, member RAS oncogene family-like; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport | 0.860 |