node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCAT2 | KLF15 | ENSP00000322991 | ENSP00000296233 | branched chain amino-acid transaminase 2, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | 0.918 |
CCDC37 | KLF15 | ENSP00000344749 | ENSP00000296233 | coiled-coil domain containing 37 | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | 0.813 |
CCDC37 | PODXL2 | ENSP00000344749 | ENSP00000345359 | coiled-coil domain containing 37 | podocalyxin-like 2; Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins | 0.860 |
CCDC37 | TMCC1 | ENSP00000344749 | ENSP00000376930 | coiled-coil domain containing 37 | transmembrane and coiled-coil domain family 1 | 0.860 |
CTGF | INS | ENSP00000356954 | ENSP00000250971 | connective tissue growth factor; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.540 |
CTGF | KLF15 | ENSP00000356954 | ENSP00000296233 | connective tissue growth factor; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | 0.841 |
FAM132A | KLF15 | ENSP00000329137 | ENSP00000296233 | family with sequence similarity 132, member A | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | 0.826 |
INS | CTGF | ENSP00000250971 | ENSP00000356954 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | connective tissue growth factor; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis | 0.540 |
INS | KLF15 | ENSP00000250971 | ENSP00000296233 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | 0.866 |
INS | MEF2A | ENSP00000250971 | ENSP00000346389 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | myocyte enhancer factor 2A | 0.468 |
INS | SLC2A4 | ENSP00000250971 | ENSP00000320935 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | 0.984 |
KLF15 | BCAT2 | ENSP00000296233 | ENSP00000322991 | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | branched chain amino-acid transaminase 2, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids | 0.918 |
KLF15 | CCDC37 | ENSP00000296233 | ENSP00000344749 | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | coiled-coil domain containing 37 | 0.813 |
KLF15 | CTGF | ENSP00000296233 | ENSP00000356954 | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | connective tissue growth factor; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis | 0.841 |
KLF15 | FAM132A | ENSP00000296233 | ENSP00000329137 | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | family with sequence similarity 132, member A | 0.826 |
KLF15 | INS | ENSP00000296233 | ENSP00000250971 | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.866 |
KLF15 | MCM7 | ENSP00000296233 | ENSP00000307288 | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | minichromosome maintenance complex component 7; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] | 0.824 |
KLF15 | MEF2A | ENSP00000296233 | ENSP00000346389 | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | myocyte enhancer factor 2A | 0.886 |
KLF15 | PODXL2 | ENSP00000296233 | ENSP00000345359 | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | podocalyxin-like 2; Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins | 0.813 |
KLF15 | SLC2A4 | ENSP00000296233 | ENSP00000320935 | Kruppel-like factor 15; Transcriptional activator. Binds to the GA element of the CLCNKA promoter | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | 0.926 |