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ESD ESD AOX1 AOX1 ALDH1B1 ALDH1B1 ALDH1A2 ALDH1A2 ADH5 ADH5 CYP26A1 CYP26A1 ALDH1A3 ALDH1A3 ALDH1A1 ALDH1A1 ALDH3B2 ALDH3B2 CYP2E1 CYP2E1 ALDH3A1 ALDH3A1
"ADH5" - alcohol dehydrogenase 5 (class III), chi polypeptide in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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experimentally determined
Predicted Interactions
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fusion edge
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textmining
coexpression edge
co-expression
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protein homology
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Score
ADH5alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (374 aa)    
Predicted Functional Partners:
ESD
esterase D; Serine hydrolase involved in the detoxification of formaldehyde (282 aa)
score_image score_image score_image score_image   score_image score_image   0.989
ALDH1A1
aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) (501 aa)
          score_image score_image   0.957
ALDH1A3
aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) (512 aa)
          score_image score_image   0.954
ALDH3A1
aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes (453 aa)
          score_image score_image   0.948
AOX1
aldehyde oxidase 1 (1338 aa)
          score_image score_image   0.947
ALDH1A2
aldehyde dehydrogenase 1 family, member A2; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity) (518 aa)
          score_image score_image   0.946
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms (493 aa)
          score_image score_image   0.945
ALDH3B2
aldehyde dehydrogenase 3 family, member B2 (385 aa)
          score_image score_image   0.944
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1; Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA (497 aa)
          score_image score_image   0.938
ALDH1B1
aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (517 aa)
          score_image score_image   0.930
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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