SLC9B1 protein (Homo sapiens) - STRING network view

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SLC9B1

solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 (515 aa)

Predicted Functional Partners:

SLC9A9

0.721

SLC9A7

0.709

TMCO3

0.680

SLC9A8

0.652

SLC9A1

0.637

BDH2

0.608

CISD2

0.605

SLC9A5

0.589

SLC9C2

0.589

NTRK1

0.581

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDH2	CISD2	ENSP00000296424	ENSP00000273986	3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity)	CDGSH iron sulfur domain 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy	0.643
BDH2	SLC9B1	ENSP00000296424	ENSP00000296422	3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity)	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	0.608
CISD2	BDH2	ENSP00000273986	ENSP00000296424	CDGSH iron sulfur domain 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy	3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity)	0.643
CISD2	SLC9B1	ENSP00000273986	ENSP00000296422	CDGSH iron sulfur domain 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	0.605
NTRK1	SLC9B1	ENSP00000431418	ENSP00000296422	neurotrophic tyrosine kinase, receptor, type 1	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	0.581
SLC9A1	SLC9B1	ENSP00000263980	ENSP00000296422	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	0.637
SLC9A1	TMCO3	ENSP00000263980	ENSP00000389399	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.500
SLC9A5	SLC9B1	ENSP00000299798	ENSP00000296422	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity)	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	0.589
SLC9A5	TMCO3	ENSP00000299798	ENSP00000389399	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity)	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.500
SLC9A7	SLC9B1	ENSP00000330320	ENSP00000296422	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	0.709
SLC9A7	TMCO3	ENSP00000330320	ENSP00000389399	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.748
SLC9A8	SLC9B1	ENSP00000354966	ENSP00000296422	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	0.652
SLC9A8	TMCO3	ENSP00000354966	ENSP00000389399	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.748
SLC9A9	SLC9B1	ENSP00000320246	ENSP00000296422	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9; May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	0.721
SLC9A9	SLC9C2	ENSP00000320246	ENSP00000356687	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9; May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell	solute carrier family 9, member C2 (putative); Involved in pH regulation (By similarity)	0.584
SLC9A9	TMCO3	ENSP00000320246	ENSP00000389399	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9; May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell	transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity)	0.748
SLC9B1	BDH2	ENSP00000296422	ENSP00000296424	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity)	0.608
SLC9B1	CISD2	ENSP00000296422	ENSP00000273986	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	CDGSH iron sulfur domain 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy	0.605
SLC9B1	NTRK1	ENSP00000296422	ENSP00000431418	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	neurotrophic tyrosine kinase, receptor, type 1	0.581
SLC9B1	SLC9A1	ENSP00000296422	ENSP00000263980	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction	0.637

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