node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AACS | BDH1 | ENSP00000324842 | ENSP00000350914 | acetoacetyl-CoA synthetase | 3-hydroxybutyrate dehydrogenase, type 1 | 0.928 |
AACS | BDH2 | ENSP00000324842 | ENSP00000296424 | acetoacetyl-CoA synthetase | 3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) | 0.911 |
AACS | HMGCL | ENSP00000324842 | ENSP00000363614 | acetoacetyl-CoA synthetase | 3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism | 0.929 |
AACS | OXCT1 | ENSP00000324842 | ENSP00000196371 | acetoacetyl-CoA synthetase | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.886 |
AACS | OXCT2 | ENSP00000324842 | ENSP00000361914 | acetoacetyl-CoA synthetase | 3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.832 |
AACS | UBC | ENSP00000324842 | ENSP00000344818 | acetoacetyl-CoA synthetase | ubiquitin C | 0.789 |
BDH1 | AACS | ENSP00000350914 | ENSP00000324842 | 3-hydroxybutyrate dehydrogenase, type 1 | acetoacetyl-CoA synthetase | 0.928 |
BDH1 | BDH2 | ENSP00000350914 | ENSP00000296424 | 3-hydroxybutyrate dehydrogenase, type 1 | 3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) | 0.952 |
BDH1 | HMGCL | ENSP00000350914 | ENSP00000363614 | 3-hydroxybutyrate dehydrogenase, type 1 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism | 0.943 |
BDH1 | OXCT1 | ENSP00000350914 | ENSP00000196371 | 3-hydroxybutyrate dehydrogenase, type 1 | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.961 |
BDH1 | OXCT2 | ENSP00000350914 | ENSP00000361914 | 3-hydroxybutyrate dehydrogenase, type 1 | 3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.906 |
BDH2 | AACS | ENSP00000296424 | ENSP00000324842 | 3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) | acetoacetyl-CoA synthetase | 0.911 |
BDH2 | BDH1 | ENSP00000296424 | ENSP00000350914 | 3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) | 3-hydroxybutyrate dehydrogenase, type 1 | 0.952 |
BDH2 | CISD2 | ENSP00000296424 | ENSP00000273986 | 3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) | CDGSH iron sulfur domain 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy | 0.643 |
BDH2 | HMGCL | ENSP00000296424 | ENSP00000363614 | 3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) | 3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism | 0.958 |
BDH2 | HMGCLL1 | ENSP00000296424 | ENSP00000381654 | 3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) | 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues | 0.680 |
BDH2 | OXCT1 | ENSP00000296424 | ENSP00000196371 | 3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.920 |
BDH2 | OXCT2 | ENSP00000296424 | ENSP00000361914 | 3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) | 3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.909 |
BDH2 | SLC9B1 | ENSP00000296424 | ENSP00000296422 | 3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) | solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 | 0.608 |
BDH2 | SLC9B2 | ENSP00000296424 | ENSP00000354574 | 3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity) | 0.649 |