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HMGCL HMGCL BDH1 BDH1 OXCT2 OXCT2 SLC9B2 SLC9B2 OXCT1 OXCT1 BDH2 BDH2 HMGCLL1 HMGCLL1 AACS AACS CISD2 CISD2 UBC UBC SLC9B1 SLC9B1
"BDH2" - 3-hydroxybutyrate dehydrogenase, type 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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protein homology
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BDH23-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) (245 aa)    
Predicted Functional Partners:
HMGCL
3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism (325 aa)
          score_image score_image   0.958
BDH1
3-hydroxybutyrate dehydrogenase, type 1 (343 aa)
          score_image score_image   0.952
OXCT1
3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) (520 aa)
score_image         score_image score_image   0.920
AACS
acetoacetyl-CoA synthetase (672 aa)
score_image     score_image   score_image score_image   0.911
OXCT2
3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) (517 aa)
score_image         score_image score_image   0.909
UBC
ubiquitin C (685 aa)
        score_image       0.864
HMGCLL1
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues (370 aa)
            score_image   0.680
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity) (537 aa)
            score_image   0.649
CISD2
CDGSH iron sulfur domain 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (135 aa)
            score_image   0.643
SLC9B1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 (515 aa)
            score_image   0.608
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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