| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALG2 | SHISA5 | ENSP00000417764 | ENSP00000296444 | asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae); Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate | shisa homolog 5 (Xenopus laevis); Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis | 0.576 |
| CD34 | MYB | ENSP00000310036 | ENSP00000339992 | CD34 molecule; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins | v-myb myeloblastosis viral oncogene homolog (avian) | 0.933 |
| CD34 | SHISA5 | ENSP00000310036 | ENSP00000296444 | CD34 molecule; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins | shisa homolog 5 (Xenopus laevis); Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis | 0.456 |
| CD34 | TP53 | ENSP00000310036 | ENSP00000269305 | CD34 molecule; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.636 |
| MYB | CD34 | ENSP00000339992 | ENSP00000310036 | v-myb myeloblastosis viral oncogene homolog (avian) | CD34 molecule; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins | 0.933 |
| MYB | SHISA5 | ENSP00000339992 | ENSP00000296444 | v-myb myeloblastosis viral oncogene homolog (avian) | shisa homolog 5 (Xenopus laevis); Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis | 0.563 |
| MYB | TP53 | ENSP00000339992 | ENSP00000269305 | v-myb myeloblastosis viral oncogene homolog (avian) | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.993 |
| SHISA5 | ALG2 | ENSP00000296444 | ENSP00000417764 | shisa homolog 5 (Xenopus laevis); Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis | asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae); Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate | 0.576 |
| SHISA5 | CD34 | ENSP00000296444 | ENSP00000310036 | shisa homolog 5 (Xenopus laevis); Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis | CD34 molecule; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins | 0.456 |
| SHISA5 | MYB | ENSP00000296444 | ENSP00000339992 | shisa homolog 5 (Xenopus laevis); Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis | v-myb myeloblastosis viral oncogene homolog (avian) | 0.563 |
| SHISA5 | TP53 | ENSP00000296444 | ENSP00000269305 | shisa homolog 5 (Xenopus laevis); Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.694 |
| SHISA5 | WWOX | ENSP00000296444 | ENSP00000457230 | shisa homolog 5 (Xenopus laevis); Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis | WW domain containing oxidoreductase | 0.564 |
| TP53 | CD34 | ENSP00000269305 | ENSP00000310036 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | CD34 molecule; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins | 0.636 |
| TP53 | MYB | ENSP00000269305 | ENSP00000339992 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | v-myb myeloblastosis viral oncogene homolog (avian) | 0.993 |
| TP53 | SHISA5 | ENSP00000269305 | ENSP00000296444 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | shisa homolog 5 (Xenopus laevis); Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis | 0.694 |
| TP53 | WWOX | ENSP00000269305 | ENSP00000457230 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | WW domain containing oxidoreductase | 0.998 |
| WWOX | SHISA5 | ENSP00000457230 | ENSP00000296444 | WW domain containing oxidoreductase | shisa homolog 5 (Xenopus laevis); Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis | 0.564 |
| WWOX | TP53 | ENSP00000457230 | ENSP00000269305 | WW domain containing oxidoreductase | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.998 |
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