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SYCE2 SYCE2 CCDC79 CCDC79 MEI1 MEI1 SYCP2 SYCP2 TSPY4 TSPY4 CCDC36 CCDC36 PASK PASK SLCO6A1 SLCO6A1 MVP MVP CCDC33 CCDC33 ADAM29 ADAM29
"CCDC36" - coiled-coil domain containing 36 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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Experiments
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[Homology]
Score
CCDC36coiled-coil domain containing 36 (594 aa)    
Predicted Functional Partners:
CCDC79
coiled-coil domain containing 79 (727 aa)
            score_image   0.766
ADAM29
ADAM metallopeptidase domain 29; May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein (820 aa)
            score_image   0.710
CCDC33
coiled-coil domain containing 33 (755 aa)
            score_image   0.680
MVP
major vault protein; Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (893 aa)
        score_image       0.661
PASK
PAS domain containing serine/threonine kinase; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis- regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha c [...] (1323 aa)
            score_image   0.636
MEI1
meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity) (1274 aa)
            score_image   0.616
SYCE2
synaptonemal complex central element protein 2; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity) (218 aa)
            score_image   0.585
SYCP2
synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements (By similarity) (1530 aa)
            score_image   0.534
TSPY4
testis specific protein, Y-linked 4; Unknown. May be involved in sperm differentiation and proliferation (By similarity) (314 aa)
            score_image   0.480
SLCO6A1
solute carrier organic anion transporter family, member 6A1 (719 aa)
            score_image   0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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