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SYBU SYBU TPRG1L TPRG1L ERC2 ERC2 BSN BSN ERC1 ERC1 UNC13A UNC13A CTBP2 CTBP2 RIMS1 RIMS1 UNC13B UNC13B RAB3A RAB3A RABAC1 RABAC1
"BSN" - bassoon (presynaptic cytomatrix protein) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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BSNbassoon (presynaptic cytomatrix protein); Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses (By similarity) (3926 aa)    
Predicted Functional Partners:
UNC13A
unc-13 homolog A (C. elegans); Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); [...] (1703 aa)
        score_image   score_image   0.974
RIMS1
regulating synaptic membrane exocytosis 1 (1692 aa)
        score_image   score_image   0.973
ERC1
ELKS/RAB6-interacting/CAST family member 1 (1116 aa)
            score_image   0.926
ERC2
ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ (957 aa)
        score_image   score_image   0.835
RAB3A
RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (220 aa)
        score_image   score_image   0.775
TPRG1L
tumor protein p63 regulated 1-like (272 aa)
            score_image   0.753
SYBU
syntabulin (syntaxin-interacting) (663 aa)
            score_image   0.744
UNC13B
unc-13 homolog B (C. elegans); Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity) (1591 aa)
            score_image   0.705
CTBP2
C-terminal binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity) (985 aa)
            score_image   0.700
RABAC1
Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity) (185 aa)
            score_image   0.666
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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