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MST1 MST1 SUMF2 SUMF2 ATF4 ATF4 ACY1 ACY1 PRDM10 PRDM10 APEH APEH UBC UBC IST1 IST1 PSENEN PSENEN APH1B APH1B PREPL PREPL
"APEH" - N-acylaminoacyl-peptide hydrolase in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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experimentally determined
Predicted Interactions
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protein homology
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APEHN-acylaminoacyl-peptide hydrolase; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (732 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.964
ATF4
activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] (351 aa)
            score_image   0.859
IST1
increased sodium tolerance 1 homolog (yeast); Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (360 aa)
        score_image       0.850
PSENEN
presenilin enhancer 2 homolog (C. elegans); Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity (101 aa)
            score_image   0.758
MST1
macrophage stimulating 1 (hepatocyte growth factor-like) (725 aa)
            score_image   0.758
ACY1
aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) (408 aa)
            score_image   0.745
APH1B
anterior pharynx defective 1 homolog B (C. elegans); Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A (257 aa)
            score_image   0.659
PREPL
prolyl endopeptidase-like (727 aa)
        score_image   score_image   0.655
SUMF2
sulfatase modifying factor 2 (358 aa)
            score_image   0.630
PRDM10
PR domain containing 10 (1160 aa)
            score_image   0.582
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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