MON1A protein (Homo sapiens) - STRING network view

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MON1A

MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity) (652 aa)

Predicted Functional Partners:

RAB7A

0.987

RAB9A

0.909

RAB9B

0.909

RABGEF1

0.896

VPS39

0.877

CCZ1

0.863

CCZ1B

0.863

KCTD7

0.764

VPS18

0.756

VPS33A

0.700

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCZ1	MON1A	ENSP00000325681	ENSP00000296473	CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	0.863
CCZ1	RAB7A	ENSP00000325681	ENSP00000265062	CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)	RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...]	0.748
CCZ1B	MON1A	ENSP00000314544	ENSP00000296473	CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	0.863
CCZ1B	RAB7A	ENSP00000314544	ENSP00000265062	CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)	RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...]	0.748
CCZ1B	RAB9B	ENSP00000314544	ENSP00000243298	CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)	RAB9B, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity)	0.420
KCTD7	MON1A	ENSP00000398177	ENSP00000296473	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	0.764
KCTD7	RAB7A	ENSP00000398177	ENSP00000265062	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...]	0.632
KCTD7	RAB9A	ENSP00000398177	ENSP00000420127	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	RAB9A, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network	0.622
KCTD7	RAB9B	ENSP00000398177	ENSP00000243298	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	RAB9B, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity)	0.402
KCTD7	RABGEF1	ENSP00000398177	ENSP00000284957	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	RAB guanine nucleotide exchange factor (GEF) 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	0.916
KCTD7	VPS39	ENSP00000398177	ENSP00000326534	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	vacuolar protein sorting 39 homolog (S. cerevisiae); May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation	0.528
MON1A	CCZ1	ENSP00000296473	ENSP00000325681	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)	0.863
MON1A	CCZ1B	ENSP00000296473	ENSP00000314544	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)	0.863
MON1A	KCTD7	ENSP00000296473	ENSP00000398177	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	0.764
MON1A	RAB7A	ENSP00000296473	ENSP00000265062	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...]	0.987
MON1A	RAB9A	ENSP00000296473	ENSP00000420127	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	RAB9A, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network	0.909
MON1A	RAB9B	ENSP00000296473	ENSP00000243298	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	RAB9B, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity)	0.909
MON1A	RABGEF1	ENSP00000296473	ENSP00000284957	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	RAB guanine nucleotide exchange factor (GEF) 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	0.896
MON1A	VPS18	ENSP00000296473	ENSP00000220509	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	vacuolar protein sorting 18 homolog (S. cerevisiae); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes	0.756
MON1A	VPS33A	ENSP00000296473	ENSP00000267199	MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity)	vacuolar protein sorting 33 homolog A (S. cerevisiae); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (By similarity)	0.700

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