node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HYPK | NAA10 | ENSP00000384474 | ENSP00000417763 | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration | 0.765 |
HYPK | NAA11 | ENSP00000384474 | ENSP00000286794 | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | N(alpha)-acetyltransferase 11, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity | 0.679 |
HYPK | NAA15 | ENSP00000384474 | ENSP00000296543 | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter | 0.967 |
HYPK | NAA20 | ENSP00000384474 | ENSP00000335636 | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | N(alpha)-acetyltransferase 20, NatB catalytic subunit; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration | 0.422 |
HYPK | NAA30 | ENSP00000384474 | ENSP00000452521 | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | N(alpha)-acetyltransferase 30, NatC catalytic subunit; Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B | 0.466 |
HYPK | NAA50 | ENSP00000384474 | ENSP00000240922 | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | N(alpha)-acetyltransferase 50, NatE catalytic subunit; Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity | 0.899 |
LSMD1 | NAA10 | ENSP00000332103 | ENSP00000417763 | LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues | N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration | 0.720 |
LSMD1 | NAA11 | ENSP00000332103 | ENSP00000286794 | LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues | N(alpha)-acetyltransferase 11, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity | 0.910 |
LSMD1 | NAA15 | ENSP00000332103 | ENSP00000296543 | LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues | N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter | 0.901 |
LSMD1 | NAA30 | ENSP00000332103 | ENSP00000452521 | LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues | N(alpha)-acetyltransferase 30, NatC catalytic subunit; Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B | 0.968 |
LSMD1 | NAA35 | ENSP00000332103 | ENSP00000354972 | LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues | N(alpha)-acetyltransferase 35, NatC auxiliary subunit; Regulates proliferation of smooth muscle cells (By similarity). Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues | 0.969 |
LSMD1 | UBC | ENSP00000332103 | ENSP00000344818 | LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues | ubiquitin C | 0.721 |
NAA10 | HYPK | ENSP00000417763 | ENSP00000384474 | N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | 0.765 |
NAA10 | LSMD1 | ENSP00000417763 | ENSP00000332103 | N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration | LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues | 0.720 |
NAA10 | NAA11 | ENSP00000417763 | ENSP00000286794 | N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration | N(alpha)-acetyltransferase 11, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity | 0.723 |
NAA10 | NAA15 | ENSP00000417763 | ENSP00000296543 | N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration | N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter | 0.989 |
NAA10 | NAA30 | ENSP00000417763 | ENSP00000452521 | N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration | N(alpha)-acetyltransferase 30, NatC catalytic subunit; Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B | 0.779 |
NAA10 | NAA35 | ENSP00000417763 | ENSP00000354972 | N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration | N(alpha)-acetyltransferase 35, NatC auxiliary subunit; Regulates proliferation of smooth muscle cells (By similarity). Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues | 0.869 |
NAA10 | NAA50 | ENSP00000417763 | ENSP00000240922 | N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration | N(alpha)-acetyltransferase 50, NatE catalytic subunit; Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity | 0.441 |
NAA11 | HYPK | ENSP00000286794 | ENSP00000384474 | N(alpha)-acetyltransferase 11, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | 0.679 |