node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL1A1 | COL1A2 | ENSP00000225964 | ENSP00000297268 | collagen, type I, alpha 1 | collagen, type I, alpha 2 | 0.963 |
COL1A1 | FLT4 | ENSP00000225964 | ENSP00000261937 | collagen, type I, alpha 1 | fms-related tyrosine kinase 4; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodi [...] | 0.908 |
COL1A1 | FN1 | ENSP00000225964 | ENSP00000346839 | collagen, type I, alpha 1 | fibronectin 1 | 0.957 |
COL1A1 | HSPG2 | ENSP00000225964 | ENSP00000363827 | collagen, type I, alpha 1 | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.608 |
COL1A1 | ITGA2 | ENSP00000225964 | ENSP00000296585 | collagen, type I, alpha 1 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | 0.985 |
COL1A1 | ITGB1 | ENSP00000225964 | ENSP00000303351 | collagen, type I, alpha 1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.973 |
COL1A1 | LUM | ENSP00000225964 | ENSP00000266718 | collagen, type I, alpha 1 | lumican | 0.861 |
COL1A2 | COL1A1 | ENSP00000297268 | ENSP00000225964 | collagen, type I, alpha 2 | collagen, type I, alpha 1 | 0.963 |
COL1A2 | FLT4 | ENSP00000297268 | ENSP00000261937 | collagen, type I, alpha 2 | fms-related tyrosine kinase 4; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodi [...] | 0.908 |
COL1A2 | FN1 | ENSP00000297268 | ENSP00000346839 | collagen, type I, alpha 2 | fibronectin 1 | 0.782 |
COL1A2 | HSPG2 | ENSP00000297268 | ENSP00000363827 | collagen, type I, alpha 2 | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.591 |
COL1A2 | ITGA2 | ENSP00000297268 | ENSP00000296585 | collagen, type I, alpha 2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | 0.983 |
COL1A2 | ITGB1 | ENSP00000297268 | ENSP00000303351 | collagen, type I, alpha 2 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.928 |
COL1A2 | LUM | ENSP00000297268 | ENSP00000266718 | collagen, type I, alpha 2 | lumican | 0.976 |
FLT4 | COL1A1 | ENSP00000261937 | ENSP00000225964 | fms-related tyrosine kinase 4; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodi [...] | collagen, type I, alpha 1 | 0.908 |
FLT4 | COL1A2 | ENSP00000261937 | ENSP00000297268 | fms-related tyrosine kinase 4; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodi [...] | collagen, type I, alpha 2 | 0.908 |
FLT4 | FN1 | ENSP00000261937 | ENSP00000346839 | fms-related tyrosine kinase 4; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodi [...] | fibronectin 1 | 0.908 |
FLT4 | ITGA2 | ENSP00000261937 | ENSP00000296585 | fms-related tyrosine kinase 4; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodi [...] | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | 0.925 |
FLT4 | ITGB1 | ENSP00000261937 | ENSP00000303351 | fms-related tyrosine kinase 4; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodi [...] | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.965 |
FN1 | COL1A1 | ENSP00000346839 | ENSP00000225964 | fibronectin 1 | collagen, type I, alpha 1 | 0.957 |