| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDA2R | SLC24A5 | ENSP00000253392 | ENSP00000341550 | ectodysplasin A2 receptor; Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 | solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.749 |
| EDA2R | SLC45A2 | ENSP00000253392 | ENSP00000296589 | ectodysplasin A2 receptor; Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 | solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity) | 0.743 |
| EDAR | SLC24A5 | ENSP00000258443 | ENSP00000341550 | ectodysplasin A receptor; Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death | solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.744 |
| EDAR | SLC45A2 | ENSP00000258443 | ENSP00000296589 | ectodysplasin A receptor; Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death | solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity) | 0.681 |
| MC1R | MITF | ENSP00000451605 | ENSP00000295600 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | microphthalmia-associated transcription factor | 0.942 |
| MC1R | OCA2 | ENSP00000451605 | ENSP00000346659 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | 0.823 |
| MC1R | SLC24A4 | ENSP00000451605 | ENSP00000431840 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.561 |
| MC1R | SLC24A5 | ENSP00000451605 | ENSP00000341550 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.700 |
| MC1R | SLC45A2 | ENSP00000451605 | ENSP00000296589 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity) | 0.658 |
| MC1R | TYR | ENSP00000451605 | ENSP00000263321 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone | 0.815 |
| MC1R | TYRP1 | ENSP00000451605 | ENSP00000373570 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | tyrosinase-related protein 1; Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized | 0.771 |
| MITF | MC1R | ENSP00000295600 | ENSP00000451605 | microphthalmia-associated transcription factor | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 0.942 |
| MITF | OCA2 | ENSP00000295600 | ENSP00000346659 | microphthalmia-associated transcription factor | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | 0.416 |
| MITF | SLC45A2 | ENSP00000295600 | ENSP00000296589 | microphthalmia-associated transcription factor | solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity) | 0.878 |
| MITF | TYR | ENSP00000295600 | ENSP00000263321 | microphthalmia-associated transcription factor | tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone | 0.871 |
| MITF | TYRP1 | ENSP00000295600 | ENSP00000373570 | microphthalmia-associated transcription factor | tyrosinase-related protein 1; Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized | 0.756 |
| OCA2 | MC1R | ENSP00000346659 | ENSP00000451605 | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 0.823 |
| OCA2 | MITF | ENSP00000346659 | ENSP00000295600 | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | microphthalmia-associated transcription factor | 0.416 |
| OCA2 | SLC24A4 | ENSP00000346659 | ENSP00000431840 | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.776 |
| OCA2 | SLC24A5 | ENSP00000346659 | ENSP00000341550 | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.877 |
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