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RAP1A RAP1A RAP1B RAP1B ABCA1 ABCA1 MAGI1 MAGI1 MAGI2 MAGI2 RAPGEF6 RAPGEF6 PTPN13 PTPN13 MAGI3 MAGI3 MRAS MRAS RAP2A RAP2A SSB SSB
"RAPGEF6" - Rap guanine nucleotide exchange factor in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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protein homology
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RAPGEF6Rap guanine nucleotide exchange factor (GEF) 6; Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP (1609 aa)    
Predicted Functional Partners:
RAP1A
RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner (184 aa)
         score_image score_image score_image   0.986
PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (2490 aa)
         score_image   score_image   0.956
RAP2A
RAP2A, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (183 aa)
         score_image   score_image   0.940
MRAS
muscle RAS oncogene homolog; May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway (208 aa)
         score_image   score_image   0.903
RAP1B
RAP1B, member of RAS oncogene family (184 aa)
         score_image score_image score_image   0.831
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1; May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity) (1462 aa)
           score_image     0.800
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2 (1455 aa)
           score_image     0.800
MAGI3
membrane associated guanylate kinase, WW and PDZ domain containing 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK sig [...] (1481 aa)
           score_image     0.800
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1 (2261 aa)
         score_image       0.576
SSB
Sjogren syndrome antigen B (autoantigen La); Binds to the 3’ poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (408 aa)
             score_image   0.485
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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