GPR85 protein (Homo sapiens) - STRING network view

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GPR85

G protein-coupled receptor 85; Orphan receptor (370 aa)

Predicted Functional Partners:

INSIG2

0.749

GPR176

0.642

INSIG1

0.610

TRAPPC2L

0.597

NMUR2

0.543

WDR44

0.535

TMEM87B

0.533

ACLY

0.530

GPR39

0.529

GPR62

0.527

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	GPR85	ENSP00000253792	ENSP00000297146	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	G protein-coupled receptor 85; Orphan receptor	0.530
ACLY	INSIG1	ENSP00000253792	ENSP00000344741	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	insulin induced gene 1; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regul [...]	0.533
GPR176	GPR85	ENSP00000453076	ENSP00000297146	G protein-coupled receptor 176; Orphan receptor	G protein-coupled receptor 85; Orphan receptor	0.642
GPR39	GPR62	ENSP00000327417	ENSP00000319250	G protein-coupled receptor 39; Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity)	G protein-coupled receptor 62; Orphan receptor	0.459
GPR39	GPR85	ENSP00000327417	ENSP00000297146	G protein-coupled receptor 39; Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity)	G protein-coupled receptor 85; Orphan receptor	0.529
GPR62	GPR39	ENSP00000319250	ENSP00000327417	G protein-coupled receptor 62; Orphan receptor	G protein-coupled receptor 39; Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity)	0.459
GPR62	GPR85	ENSP00000319250	ENSP00000297146	G protein-coupled receptor 62; Orphan receptor	G protein-coupled receptor 85; Orphan receptor	0.527
GPR62	NMUR2	ENSP00000319250	ENSP00000255262	G protein-coupled receptor 62; Orphan receptor	neuromedin U receptor 2; Receptor for the neuromedin-U and neuromedin-S neuropeptides (By similarity)	0.524
GPR85	ACLY	ENSP00000297146	ENSP00000253792	G protein-coupled receptor 85; Orphan receptor	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	0.530
GPR85	GPR176	ENSP00000297146	ENSP00000453076	G protein-coupled receptor 85; Orphan receptor	G protein-coupled receptor 176; Orphan receptor	0.642
GPR85	GPR39	ENSP00000297146	ENSP00000327417	G protein-coupled receptor 85; Orphan receptor	G protein-coupled receptor 39; Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity)	0.529
GPR85	GPR62	ENSP00000297146	ENSP00000319250	G protein-coupled receptor 85; Orphan receptor	G protein-coupled receptor 62; Orphan receptor	0.527
GPR85	INSIG1	ENSP00000297146	ENSP00000344741	G protein-coupled receptor 85; Orphan receptor	insulin induced gene 1; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regul [...]	0.610
GPR85	INSIG2	ENSP00000297146	ENSP00000245787	G protein-coupled receptor 85; Orphan receptor	insulin induced gene 2; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR	0.749
GPR85	NMUR2	ENSP00000297146	ENSP00000255262	G protein-coupled receptor 85; Orphan receptor	neuromedin U receptor 2; Receptor for the neuromedin-U and neuromedin-S neuropeptides (By similarity)	0.543
GPR85	TMEM87B	ENSP00000297146	ENSP00000283206	G protein-coupled receptor 85; Orphan receptor	transmembrane protein 87B	0.533
GPR85	TRAPPC2L	ENSP00000297146	ENSP00000301021	G protein-coupled receptor 85; Orphan receptor	trafficking protein particle complex 2-like; May play a role in vesicular transport from endoplasmic reticulum to Golgi	0.597
GPR85	WDR44	ENSP00000297146	ENSP00000254029	G protein-coupled receptor 85; Orphan receptor	WD repeat domain 44	0.535
INSIG1	ACLY	ENSP00000344741	ENSP00000253792	insulin induced gene 1; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regul [...]	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	0.533
INSIG1	GPR85	ENSP00000344741	ENSP00000297146	insulin induced gene 1; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regul [...]	G protein-coupled receptor 85; Orphan receptor	0.610

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