node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGTRAP | BST2 | ENSP00000319713 | ENSP00000252593 | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | bone marrow stromal cell antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retrovirid [...] | 0.660 |
AGTRAP | CAMLG | ENSP00000319713 | ENSP00000297156 | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | 0.949 |
BST2 | AGTRAP | ENSP00000252593 | ENSP00000319713 | bone marrow stromal cell antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retrovirid [...] | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | 0.660 |
BST2 | CAMLG | ENSP00000252593 | ENSP00000297156 | bone marrow stromal cell antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retrovirid [...] | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | 0.689 |
CAMLG | AGTRAP | ENSP00000297156 | ENSP00000319713 | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | 0.949 |
CAMLG | BST2 | ENSP00000297156 | ENSP00000252593 | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | bone marrow stromal cell antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retrovirid [...] | 0.689 |
CAMLG | EGFR | ENSP00000297156 | ENSP00000275493 | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | epidermal growth factor receptor | 0.795 |
CAMLG | LCK | ENSP00000297156 | ENSP00000337825 | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | lymphocyte-specific protein tyrosine kinase | 0.845 |
CAMLG | PKHD1 | ENSP00000297156 | ENSP00000360158 | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | polycystic kidney and hepatic disease 1 (autosomal recessive); May be required for correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly. May be a receptor protein that acts in collecting-duct and biliary differentiation | 0.926 |
CAMLG | PRLR | ENSP00000297156 | ENSP00000371432 | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | prolactin receptor | 0.810 |
CAMLG | RNF122 | ENSP00000297156 | ENSP00000256257 | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | ring finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability | 0.924 |
CAMLG | TMUB1 | ENSP00000297156 | ENSP00000297533 | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | transmembrane and ubiquitin-like domain containing 1; May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity) | 0.941 |
CAMLG | TNFRSF13B | ENSP00000297156 | ENSP00000261652 | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | tumor necrosis factor receptor superfamily, member 13B; Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T- cell function and the regulation of humoral immunity | 0.941 |
CAMLG | TNFSF13B | ENSP00000297156 | ENSP00000365048 | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | tumor necrosis factor (ligand) superfamily, member 13b; Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response | 0.769 |
EGFR | CAMLG | ENSP00000275493 | ENSP00000297156 | epidermal growth factor receptor | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | 0.795 |
EGFR | LCK | ENSP00000275493 | ENSP00000337825 | epidermal growth factor receptor | lymphocyte-specific protein tyrosine kinase | 0.926 |
EGFR | PKHD1 | ENSP00000275493 | ENSP00000360158 | epidermal growth factor receptor | polycystic kidney and hepatic disease 1 (autosomal recessive); May be required for correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly. May be a receptor protein that acts in collecting-duct and biliary differentiation | 0.406 |
EGFR | PRLR | ENSP00000275493 | ENSP00000371432 | epidermal growth factor receptor | prolactin receptor | 0.480 |
LCK | CAMLG | ENSP00000337825 | ENSP00000297156 | lymphocyte-specific protein tyrosine kinase | calcium modulating ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | 0.845 |
LCK | EGFR | ENSP00000337825 | ENSP00000275493 | lymphocyte-specific protein tyrosine kinase | epidermal growth factor receptor | 0.926 |