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STOM STOM NRXN1 NRXN1 ENSG00000256500 ENSG00000256500 KLC1 KLC1 ARMC6 ARMC6 SYTL3 SYTL3 STOML3 STOML3 RAB10 RAB10 RAB27A RAB27A SYNE1 SYNE1 SYNGR4 SYNGR4
"SYTL3" - synaptotagmin-like 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
SYTL3synaptotagmin-like 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity) (610 aa)    
Predicted Functional Partners:
RAB27A
RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse (221 aa)
        score_image   score_image   0.882
ENSG00000256500
Kinesin light chain 1 (732 aa)
            score_image   0.808
KLC1
kinesin light chain 1 (618 aa)
            score_image   0.804
STOM
stomatin; Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity) (288 aa)
            score_image   0.740
STOML3
stomatin (EPB72)-like 3 (291 aa)
            score_image   0.662
ARMC6
armadillo repeat containing 6 (501 aa)
            score_image   0.636
RAB10
RAB10, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transpo [...] (200 aa)
        score_image   score_image   0.609
SYNGR4
synaptogyrin 4 (234 aa)
      score_image     score_image   0.594
NRXN1
neurexin 1; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity) (1547 aa)
        score_image       0.576
SYNE1
spectrin repeat containing, nuclear envelope 1 (8797 aa)
            score_image   0.540
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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