node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FNDC1 | GNB1 | ENSP00000297267 | ENSP00000367869 | fibronectin type III domain containing 1 | guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | 0.668 |
FNDC1 | GNG2 | ENSP00000297267 | ENSP00000334448 | fibronectin type III domain containing 1 | guanine nucleotide binding protein (G protein), gamma 2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) | 0.686 |
FNDC1 | IQSEC1 | ENSP00000297267 | ENSP00000273221 | fibronectin type III domain containing 1 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | 0.691 |
FNDC1 | IQSEC2 | ENSP00000297267 | ENSP00000379712 | fibronectin type III domain containing 1 | IQ motif and Sec7 domain 2 | 0.691 |
FNDC1 | IQSEC3 | ENSP00000297267 | ENSP00000315662 | fibronectin type III domain containing 1 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | 0.691 |
FNDC1 | NTN1 | ENSP00000297267 | ENSP00000173229 | fibronectin type III domain containing 1 | netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.803 |
FNDC1 | NTN3 | ENSP00000297267 | ENSP00000293973 | fibronectin type III domain containing 1 | netrin 3; Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity) | 0.798 |
FNDC1 | NTN5 | ENSP00000297267 | ENSP00000270235 | fibronectin type III domain containing 1 | netrin 5 | 0.798 |
FNDC1 | NTNG1 | ENSP00000297267 | ENSP00000359085 | fibronectin type III domain containing 1 | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.819 |
FNDC1 | NTNG2 | ENSP00000297267 | ENSP00000376921 | fibronectin type III domain containing 1 | netrin G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.798 |
GNB1 | FNDC1 | ENSP00000367869 | ENSP00000297267 | guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | fibronectin type III domain containing 1 | 0.668 |
GNB1 | GNG2 | ENSP00000367869 | ENSP00000334448 | guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | guanine nucleotide binding protein (G protein), gamma 2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) | 0.999 |
GNG2 | FNDC1 | ENSP00000334448 | ENSP00000297267 | guanine nucleotide binding protein (G protein), gamma 2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) | fibronectin type III domain containing 1 | 0.686 |
GNG2 | GNB1 | ENSP00000334448 | ENSP00000367869 | guanine nucleotide binding protein (G protein), gamma 2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) | guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | 0.999 |
IQSEC1 | FNDC1 | ENSP00000273221 | ENSP00000297267 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | fibronectin type III domain containing 1 | 0.691 |
IQSEC1 | NTN1 | ENSP00000273221 | ENSP00000173229 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.631 |
IQSEC1 | NTN3 | ENSP00000273221 | ENSP00000293973 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | netrin 3; Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity) | 0.624 |
IQSEC1 | NTN5 | ENSP00000273221 | ENSP00000270235 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | netrin 5 | 0.602 |
IQSEC1 | NTNG1 | ENSP00000273221 | ENSP00000359085 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.607 |
IQSEC1 | NTNG2 | ENSP00000273221 | ENSP00000376921 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | netrin G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.602 |