PGAM2 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PGAM2

phosphoglycerate mutase 2 (muscle); Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity (253 aa)

Predicted Functional Partners:

PGK2

0.993

ENO3

0.987

UBC

0.986

GPI

0.962

ALDOC

0.945

ALDOA

0.943

ALDOB

0.939

PGK1

0.921

GLYCTK

0.921

PHGDH

0.919

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDOA	ALDOB	ENSP00000336927	ENSP00000363988	aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)	aldolase B, fructose-bisphosphate	0.829
ALDOA	ALDOC	ENSP00000336927	ENSP00000226253	aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)	aldolase C, fructose-bisphosphate	0.981
ALDOA	ENO3	ENSP00000336927	ENSP00000324105	aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	0.985
ALDOA	GPI	ENSP00000336927	ENSP00000405573	aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)	glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons	0.980
ALDOA	PGAM2	ENSP00000336927	ENSP00000297283	aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)	phosphoglycerate mutase 2 (muscle); Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity	0.943
ALDOA	PGK1	ENSP00000336927	ENSP00000362413	aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)	phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein)	0.897
ALDOA	PGK2	ENSP00000336927	ENSP00000305995	aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)	phosphoglycerate kinase 2	0.844
ALDOA	UBC	ENSP00000336927	ENSP00000344818	aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)	ubiquitin C	0.999
ALDOB	ALDOA	ENSP00000363988	ENSP00000336927	aldolase B, fructose-bisphosphate	aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)	0.829
ALDOB	ALDOC	ENSP00000363988	ENSP00000226253	aldolase B, fructose-bisphosphate	aldolase C, fructose-bisphosphate	0.805
ALDOB	ENO3	ENSP00000363988	ENSP00000324105	aldolase B, fructose-bisphosphate	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	0.981
ALDOB	GPI	ENSP00000363988	ENSP00000405573	aldolase B, fructose-bisphosphate	glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons	0.980
ALDOB	PGAM2	ENSP00000363988	ENSP00000297283	aldolase B, fructose-bisphosphate	phosphoglycerate mutase 2 (muscle); Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity	0.939
ALDOB	PGK1	ENSP00000363988	ENSP00000362413	aldolase B, fructose-bisphosphate	phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein)	0.822
ALDOB	PGK2	ENSP00000363988	ENSP00000305995	aldolase B, fructose-bisphosphate	phosphoglycerate kinase 2	0.845
ALDOB	UBC	ENSP00000363988	ENSP00000344818	aldolase B, fructose-bisphosphate	ubiquitin C	0.752
ALDOC	ALDOA	ENSP00000226253	ENSP00000336927	aldolase C, fructose-bisphosphate	aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)	0.981
ALDOC	ALDOB	ENSP00000226253	ENSP00000363988	aldolase C, fructose-bisphosphate	aldolase B, fructose-bisphosphate	0.805
ALDOC	ENO3	ENSP00000226253	ENSP00000324105	aldolase C, fructose-bisphosphate	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	0.981
ALDOC	GPI	ENSP00000226253	ENSP00000405573	aldolase C, fructose-bisphosphate	glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons	0.982

page 1 of 4

Experiments

Neighborhood

Databases

Fusion

Textmining

Cooccurrence

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About