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STRINGSTRING
SYNE3 SYNE3 SYNE2 SYNE2 SYNE1 SYNE1 SUN1 SUN1 TRIM50 TRIM50 ACACA ACACA ACACB ACACB SUN3 SUN3 CT45A5 CT45A5 C7orf57 C7orf57 HAO2 HAO2
"SUN3" - Sad1 and UNC84 domain containing 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SUN3Sad1 and UNC84 domain containing 3 (357 aa)    
Predicted Functional Partners:
ACACA
acetyl-CoA carboxylase alpha (2383 aa)
        score_image       0.810
ACACB
acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
        score_image       0.810
SYNE1
spectrin repeat containing, nuclear envelope 1 (8797 aa)
          score_image score_image   0.638
SYNE2
spectrin repeat containing, nuclear envelope 2 (6907 aa)
          score_image score_image   0.585
C7orf57
chromosome 7 open reading frame 57 (295 aa)
            score_image   0.581
CT45A5
cancer/testis antigen family 45, member A5 (189 aa)
            score_image   0.469
SYNE3
spectrin repeat containing, nuclear envelope family member 3; Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is requ [...] (975 aa)
          score_image score_image   0.466
SUN1
Sad1 and UNC84 domain containing 1 (785 aa)
          score_image score_image score_image 0.407
HAO2
hydroxyacid oxidase 2 (long chain); Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids (351 aa)
            score_image   0.402
TRIM50
tripartite motif containing 50; E3 ubiquitin-protein ligase (487 aa)
            score_image   0.401
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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