node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNPY1 | EN2 | ENSP00000317439 | ENSP00000297375 | canopy 1 homolog (zebrafish) | engrailed homeobox 2 | 0.822 |
CNPY1 | FGF8 | ENSP00000317439 | ENSP00000321797 | canopy 1 homolog (zebrafish) | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.898 |
DHH | EN2 | ENSP00000266991 | ENSP00000297375 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | engrailed homeobox 2 | 0.817 |
DHH | FGF8 | ENSP00000266991 | ENSP00000321797 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.481 |
DHH | WNT1 | ENSP00000266991 | ENSP00000293549 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | wingless-type MMTV integration site family, member 1; Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters | 0.801 |
DHH | WNT3A | ENSP00000266991 | ENSP00000284523 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | wingless-type MMTV integration site family, member 3A; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube | 0.791 |
EGR2 | EN2 | ENSP00000242480 | ENSP00000297375 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | engrailed homeobox 2 | 0.846 |
EGR2 | FGF8 | ENSP00000242480 | ENSP00000321797 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.679 |
EGR2 | SHH | ENSP00000242480 | ENSP00000297261 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.559 |
EGR2 | WNT3A | ENSP00000242480 | ENSP00000284523 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | wingless-type MMTV integration site family, member 3A; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube | 0.868 |
EN2 | CNPY1 | ENSP00000297375 | ENSP00000317439 | engrailed homeobox 2 | canopy 1 homolog (zebrafish) | 0.822 |
EN2 | DHH | ENSP00000297375 | ENSP00000266991 | engrailed homeobox 2 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | 0.817 |
EN2 | EGR2 | ENSP00000297375 | ENSP00000242480 | engrailed homeobox 2 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | 0.846 |
EN2 | FGF8 | ENSP00000297375 | ENSP00000321797 | engrailed homeobox 2 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.904 |
EN2 | NF2 | ENSP00000297375 | ENSP00000344666 | engrailed homeobox 2 | neurofibromin 2 (merlin) | 0.877 |
EN2 | SHH | ENSP00000297375 | ENSP00000297261 | engrailed homeobox 2 | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.969 |
EN2 | TLE4 | ENSP00000297375 | ENSP00000365735 | engrailed homeobox 2 | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 0.945 |
EN2 | WNT1 | ENSP00000297375 | ENSP00000293549 | engrailed homeobox 2 | wingless-type MMTV integration site family, member 1; Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters | 0.851 |
EN2 | WNT3A | ENSP00000297375 | ENSP00000284523 | engrailed homeobox 2 | wingless-type MMTV integration site family, member 3A; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube | 0.950 |
EN2 | ZIC1 | ENSP00000297375 | ENSP00000282928 | engrailed homeobox 2 | Zic family member 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Bin [...] | 0.929 |