node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KCNAB1 | KCNAB2 | ENSP00000419952 | ENSP00000367323 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | 0.902 |
KCNAB1 | KCNAB3 | ENSP00000419952 | ENSP00000302719 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, shaker-related subfamily, beta member 3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5 | 0.903 |
KCNAB1 | KCNB1 | ENSP00000419952 | ENSP00000360806 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, Shab-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient | 0.957 |
KCNAB1 | KCNB2 | ENSP00000419952 | ENSP00000430846 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, Shab-related subfamily, member 2; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient | 0.938 |
KCNAB1 | KCNH1 | ENSP00000419952 | ENSP00000271751 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | 0.924 |
KCNAB1 | KCNH2 | ENSP00000419952 | ENSP00000262186 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | 0.942 |
KCNAB1 | KCNH4 | ENSP00000419952 | ENSP00000264661 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 4; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly | 0.919 |
KCNAB1 | KCNH5 | ENSP00000419952 | ENSP00000321427 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 5; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly | 0.920 |
KCNAB1 | KCNH7 | ENSP00000419952 | ENSP00000331727 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 7; Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly | 0.924 |
KCNAB1 | KCNV1 | ENSP00000419952 | ENSP00000297404 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium channel, subfamily V, member 1; Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes | 0.963 |
KCNAB2 | KCNAB1 | ENSP00000367323 | ENSP00000419952 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | 0.902 |
KCNAB2 | KCNAB3 | ENSP00000367323 | ENSP00000302719 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, shaker-related subfamily, beta member 3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5 | 0.903 |
KCNAB2 | KCNB1 | ENSP00000367323 | ENSP00000360806 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, Shab-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient | 0.949 |
KCNAB2 | KCNB2 | ENSP00000367323 | ENSP00000430846 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, Shab-related subfamily, member 2; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient | 0.933 |
KCNAB2 | KCNH1 | ENSP00000367323 | ENSP00000271751 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | 0.929 |
KCNAB2 | KCNH2 | ENSP00000367323 | ENSP00000262186 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | 0.933 |
KCNAB2 | KCNH4 | ENSP00000367323 | ENSP00000264661 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, subfamily H (eag-related), member 4; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly | 0.917 |
KCNAB2 | KCNH5 | ENSP00000367323 | ENSP00000321427 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, subfamily H (eag-related), member 5; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly | 0.928 |
KCNAB2 | KCNH7 | ENSP00000367323 | ENSP00000331727 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, subfamily H (eag-related), member 7; Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly | 0.920 |
KCNAB2 | KCNV1 | ENSP00000367323 | ENSP00000297404 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium channel, subfamily V, member 1; Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes | 0.958 |