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STRINGSTRING
GDF6 GDF6 EXT1 EXT1 ANXA13 ANXA13 TRPS1 TRPS1 CNTNAP2 CNTNAP2 FTSJD1 FTSJD1 CSMD3 CSMD3 UBC UBC PER1 PER1 NUDT8 NUDT8 TXNDC2 TXNDC2
"CSMD3" - CUB and Sushi multiple domains 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
CSMD3CUB and Sushi multiple domains 3 (3707 aa)    
Predicted Functional Partners:
ANXA13
annexin A13 (357 aa)
            score_image   0.814
TRPS1
trichorhinophalangeal syndrome I; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes (1294 aa)
            score_image   0.757
FTSJD1
FtsJ methyltransferase domain containing 1 (770 aa)
            score_image   0.757
EXT1
exostosin 1; Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor (746 aa)
            score_image   0.660
GDF6
growth differentiation factor 6; Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development (By similarity) (455 aa)
            score_image   0.607
PER1
period homolog 1 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Can bind heme (By similarity) (1290 aa)
            score_image   0.525
TXNDC2
thioredoxin domain containing 2 (spermatozoa); Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase (553 aa)
            score_image   0.491
UBC
ubiquitin C (685 aa)
        score_image       0.486
CNTNAP2
contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction (1331 aa)
            score_image   0.473
NUDT8
nudix (nucleoside diphosphate linked moiety X)-type motif 8; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity) (140 aa)
            score_image   0.472
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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