node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | CAMP | ENSP00000295897 | ENSP00000458149 | albumin | cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity | 0.475 |
ALB | DEFB1 | ENSP00000295897 | ENSP00000297439 | albumin | defensin, beta 1; Has bactericidal activity (By similarity) | 0.865 |
ALB | MYC | ENSP00000295897 | ENSP00000367207 | albumin | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.943 |
CAMP | ALB | ENSP00000458149 | ENSP00000295897 | cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity | albumin | 0.475 |
CAMP | DEFA3 | ENSP00000458149 | ENSP00000328359 | cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity | defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane | 0.644 |
CAMP | DEFA4 | ENSP00000458149 | ENSP00000297435 | cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity | defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production | 0.565 |
CAMP | DEFA6 | ENSP00000458149 | ENSP00000297436 | cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity | defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1 | 0.445 |
CAMP | DEFB1 | ENSP00000458149 | ENSP00000297439 | cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity | defensin, beta 1; Has bactericidal activity (By similarity) | 0.817 |
CCR6 | DEFB1 | ENSP00000339393 | ENSP00000297439 | chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level | defensin, beta 1; Has bactericidal activity (By similarity) | 0.965 |
CCR6 | DEFB4A | ENSP00000339393 | ENSP00000303532 | chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level | defensin, beta 4A; Has antibacterial activity (Potential) | 0.576 |
DEFA3 | CAMP | ENSP00000328359 | ENSP00000458149 | defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane | cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity | 0.644 |
DEFA3 | DEFA4 | ENSP00000328359 | ENSP00000297435 | defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane | defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production | 0.907 |
DEFA3 | DEFA5 | ENSP00000328359 | ENSP00000329890 | defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane | defensin, alpha 5, Paneth cell-specific; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing | 0.905 |
DEFA3 | DEFA6 | ENSP00000328359 | ENSP00000297436 | defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane | defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1 | 0.907 |
DEFA3 | DEFB1 | ENSP00000328359 | ENSP00000297439 | defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane | defensin, beta 1; Has bactericidal activity (By similarity) | 0.973 |
DEFA3 | DEFB4A | ENSP00000328359 | ENSP00000303532 | defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane | defensin, beta 4A; Has antibacterial activity (Potential) | 0.414 |
DEFA4 | CAMP | ENSP00000297435 | ENSP00000458149 | defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production | cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity | 0.565 |
DEFA4 | DEFA3 | ENSP00000297435 | ENSP00000328359 | defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production | defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane | 0.907 |
DEFA4 | DEFA5 | ENSP00000297435 | ENSP00000329890 | defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production | defensin, alpha 5, Paneth cell-specific; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing | 0.905 |
DEFA4 | DEFA6 | ENSP00000297435 | ENSP00000297436 | defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production | defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1 | 0.907 |