node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC4 | CCDC164 | ENSP00000306410 | ENSP00000288710 | armadillo repeat containing 4 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | 0.721 |
ARMC4 | CCDC39 | ENSP00000306410 | ENSP00000405708 | armadillo repeat containing 4 | coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly | 0.689 |
ARMC4 | CCDC40 | ENSP00000306410 | ENSP00000380679 | armadillo repeat containing 4 | coiled-coil domain containing 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 | 0.670 |
ARMC4 | CCDC65 | ENSP00000306410 | ENSP00000312706 | armadillo repeat containing 4 | coiled-coil domain containing 65 | 0.708 |
ARMC4 | DNAAF2 | ENSP00000306410 | ENSP00000298292 | armadillo repeat containing 4 | dynein, axonemal, assembly factor 2; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment | 0.586 |
ARMC4 | DNAAF3 | ENSP00000306410 | ENSP00000375599 | armadillo repeat containing 4 | dynein, axonemal, assembly factor 3; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia | 0.693 |
ARMC4 | DYX1C1 | ENSP00000306410 | ENSP00000323275 | armadillo repeat containing 4 | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.640 |
ARMC4 | HEATR2 | ENSP00000306410 | ENSP00000297440 | armadillo repeat containing 4 | HEAT repeat containing 2 | 0.674 |
ARMC4 | SPAG1 | ENSP00000306410 | ENSP00000251809 | armadillo repeat containing 4 | sperm associated antigen 1; Plays a role in fertilization. Binds GTP and has GTPase activity | 0.617 |
ARMC4 | UBC | ENSP00000306410 | ENSP00000344818 | armadillo repeat containing 4 | ubiquitin C | 0.594 |
CCDC164 | ARMC4 | ENSP00000288710 | ENSP00000306410 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | armadillo repeat containing 4 | 0.721 |
CCDC164 | CCDC39 | ENSP00000288710 | ENSP00000405708 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly | 0.758 |
CCDC164 | CCDC40 | ENSP00000288710 | ENSP00000380679 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | coiled-coil domain containing 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 | 0.777 |
CCDC164 | CCDC65 | ENSP00000288710 | ENSP00000312706 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | coiled-coil domain containing 65 | 0.828 |
CCDC164 | DNAAF2 | ENSP00000288710 | ENSP00000298292 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | dynein, axonemal, assembly factor 2; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment | 0.713 |
CCDC164 | DNAAF3 | ENSP00000288710 | ENSP00000375599 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | dynein, axonemal, assembly factor 3; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia | 0.762 |
CCDC164 | DYX1C1 | ENSP00000288710 | ENSP00000323275 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.688 |
CCDC164 | HEATR2 | ENSP00000288710 | ENSP00000297440 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | HEAT repeat containing 2 | 0.748 |
CCDC164 | SPAG1 | ENSP00000288710 | ENSP00000251809 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | sperm associated antigen 1; Plays a role in fertilization. Binds GTP and has GTPase activity | 0.697 |
CCDC39 | ARMC4 | ENSP00000405708 | ENSP00000306410 | coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly | armadillo repeat containing 4 | 0.689 |