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STRINGSTRING
DNAAF3 DNAAF3 HEATR2 HEATR2 DYX1C1 DYX1C1 CCDC40 CCDC40 UBC UBC ARMC4 ARMC4 CCDC39 CCDC39 CCDC164 CCDC164 SPAG1 SPAG1 DNAAF2 DNAAF2 CCDC65 CCDC65
"HEATR2" - HEAT repeat containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HEATR2HEAT repeat containing 2 (855 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.938
DNAAF3
dynein, axonemal, assembly factor 3; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia (588 aa)
            score_image   0.775
CCDC40
coiled-coil domain containing 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (1142 aa)
            score_image   0.759
CCDC164
coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending (740 aa)
            score_image   0.748
CCDC65
coiled-coil domain containing 65 (484 aa)
            score_image   0.726
CCDC39
coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly (941 aa)
            score_image   0.718
DNAAF2
dynein, axonemal, assembly factor 2; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment (837 aa)
            score_image   0.687
ARMC4
armadillo repeat containing 4 (1044 aa)
            score_image   0.674
DYX1C1
dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity (420 aa)
            score_image   0.651
SPAG1
sperm associated antigen 1; Plays a role in fertilization. Binds GTP and has GTPase activity (926 aa)
            score_image   0.650
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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