node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CANX | ERLIN2 | ENSP00000247461 | ENSP00000276461 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | 0.502 |
CANX | KIAA1161 | ENSP00000247461 | ENSP00000297625 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | KIAA1161; Putative glucosidase (By similarity) | 0.551 |
CANX | PRKCSH | ENSP00000247461 | ENSP00000252455 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | protein kinase C substrate 80K-H; Regulatory subunit of glucosidase II | 0.999 |
ERLIN2 | CANX | ENSP00000276461 | ENSP00000247461 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.502 |
ERLIN2 | KIAA1161 | ENSP00000276461 | ENSP00000297625 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | KIAA1161; Putative glucosidase (By similarity) | 0.561 |
ERLIN2 | PPAPDC3 | ENSP00000276461 | ENSP00000361338 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) | 0.517 |
ERLIN2 | TOR1AIP2 | ENSP00000276461 | ENSP00000356584 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | torsin A interacting protein 2; Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope | 0.620 |
GNPTG | KIAA1161 | ENSP00000204679 | ENSP00000297625 | N-acetylglucosamine-1-phosphate transferase, gamma subunit; May recognize the substrate of GlcNAc-1- phosphotransferase but also the lysosomal proteins with mannose-6- phosphate residues | KIAA1161; Putative glucosidase (By similarity) | 0.481 |
KIAA1161 | CANX | ENSP00000297625 | ENSP00000247461 | KIAA1161; Putative glucosidase (By similarity) | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.551 |
KIAA1161 | ERLIN2 | ENSP00000297625 | ENSP00000276461 | KIAA1161; Putative glucosidase (By similarity) | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | 0.561 |
KIAA1161 | GNPTG | ENSP00000297625 | ENSP00000204679 | KIAA1161; Putative glucosidase (By similarity) | N-acetylglucosamine-1-phosphate transferase, gamma subunit; May recognize the substrate of GlcNAc-1- phosphotransferase but also the lysosomal proteins with mannose-6- phosphate residues | 0.481 |
KIAA1161 | LEMD2 | ENSP00000297625 | ENSP00000293760 | KIAA1161; Putative glucosidase (By similarity) | LEM domain containing 2; Involved in nuclear structure organization | 0.472 |
KIAA1161 | MANBA | ENSP00000297625 | ENSP00000226578 | KIAA1161; Putative glucosidase (By similarity) | mannosidase, beta A, lysosomal; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides | 0.560 |
KIAA1161 | PPAPDC3 | ENSP00000297625 | ENSP00000361338 | KIAA1161; Putative glucosidase (By similarity) | phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) | 0.726 |
KIAA1161 | PRKCSH | ENSP00000297625 | ENSP00000252455 | KIAA1161; Putative glucosidase (By similarity) | protein kinase C substrate 80K-H; Regulatory subunit of glucosidase II | 0.481 |
KIAA1161 | SMPD4 | ENSP00000297625 | ENSP00000386531 | KIAA1161; Putative glucosidase (By similarity) | sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) | 0.488 |
KIAA1161 | SYNE3 | ENSP00000297625 | ENSP00000334308 | KIAA1161; Putative glucosidase (By similarity) | spectrin repeat containing, nuclear envelope family member 3; Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is requ [...] | 0.694 |
KIAA1161 | TOR1AIP2 | ENSP00000297625 | ENSP00000356584 | KIAA1161; Putative glucosidase (By similarity) | torsin A interacting protein 2; Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope | 0.752 |
LEMD2 | KIAA1161 | ENSP00000293760 | ENSP00000297625 | LEM domain containing 2; Involved in nuclear structure organization | KIAA1161; Putative glucosidase (By similarity) | 0.472 |
LEMD2 | PPAPDC3 | ENSP00000293760 | ENSP00000361338 | LEM domain containing 2; Involved in nuclear structure organization | phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) | 0.414 |