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STRINGSTRING
LEMD2 LEMD2 PPAPDC3 PPAPDC3 SYNE3 SYNE3 ERLIN2 ERLIN2 TOR1AIP2 TOR1AIP2 CANX CANX KIAA1161 KIAA1161 SMPD4 SMPD4 PRKCSH PRKCSH MANBA MANBA GNPTG GNPTG
KIAA1161 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
KIAA1161KIAA1161; Putative glucosidase (By similarity) (680 aa)    
Predicted Functional Partners:
TOR1AIP2
torsin A interacting protein 2; Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope (470 aa)
            score_image   0.752
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) (271 aa)
            score_image   0.726
SYNE3
spectrin repeat containing, nuclear envelope family member 3; Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is requ [...] (975 aa)
            score_image   0.694
ERLIN2
ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway (339 aa)
            score_image   0.561
MANBA
mannosidase, beta A, lysosomal; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides (879 aa)
            score_image   0.560
CANX
calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] (592 aa)
        score_image   score_image   0.551
SMPD4
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) (866 aa)
            score_image   0.488
PRKCSH
protein kinase C substrate 80K-H; Regulatory subunit of glucosidase II (528 aa)
        score_image   score_image   0.481
GNPTG
N-acetylglucosamine-1-phosphate transferase, gamma subunit; May recognize the substrate of GlcNAc-1- phosphotransferase but also the lysosomal proteins with mannose-6- phosphate residues (305 aa)
        score_image   score_image   0.481
LEMD2
LEM domain containing 2; Involved in nuclear structure organization (503 aa)
            score_image   0.472
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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