TMEM65 protein (Homo sapiens) - STRING network view

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TMEM65

transmembrane protein 65 (240 aa)

Predicted Functional Partners:

ACAA2

0.972

TAX1BP3

0.926

RTN4

0.909

S100A10

0.809

SRPRB

0.644

NDUFS6

0.644

ACAT1

0.644

GAK

0.426

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA2	ACAT1	ENSP00000285093	ENSP00000265838	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.972
ACAA2	RTN4	ENSP00000285093	ENSP00000337838	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	reticulon 4	0.659
ACAA2	TAX1BP3	ENSP00000285093	ENSP00000225525	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6	0.969
ACAA2	TMEM65	ENSP00000285093	ENSP00000297632	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	transmembrane protein 65	0.972
ACAT1	ACAA2	ENSP00000265838	ENSP00000285093	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.972
ACAT1	TMEM65	ENSP00000265838	ENSP00000297632	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	transmembrane protein 65	0.644
GAK	TMEM65	ENSP00000314499	ENSP00000297632	cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1	transmembrane protein 65	0.426
NDUFS6	TMEM65	ENSP00000274137	ENSP00000297632	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase); Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	transmembrane protein 65	0.644
RTN4	ACAA2	ENSP00000337838	ENSP00000285093	reticulon 4	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.659
RTN4	TMEM65	ENSP00000337838	ENSP00000297632	reticulon 4	transmembrane protein 65	0.909
S100A10	SRPRB	ENSP00000357799	ENSP00000418401	S100 calcium binding protein A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase	signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)	0.649
S100A10	TMEM65	ENSP00000357799	ENSP00000297632	S100 calcium binding protein A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase	transmembrane protein 65	0.809
SRPRB	S100A10	ENSP00000418401	ENSP00000357799	signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)	S100 calcium binding protein A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase	0.649
SRPRB	TMEM65	ENSP00000418401	ENSP00000297632	signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)	transmembrane protein 65	0.644
TAX1BP3	ACAA2	ENSP00000225525	ENSP00000285093	Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.969
TAX1BP3	TMEM65	ENSP00000225525	ENSP00000297632	Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6	transmembrane protein 65	0.926
TMEM65	ACAA2	ENSP00000297632	ENSP00000285093	transmembrane protein 65	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.972
TMEM65	ACAT1	ENSP00000297632	ENSP00000265838	transmembrane protein 65	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.644
TMEM65	GAK	ENSP00000297632	ENSP00000314499	transmembrane protein 65	cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1	0.426
TMEM65	NDUFS6	ENSP00000297632	ENSP00000274137	transmembrane protein 65	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase); Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	0.644

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