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HECTD4 HECTD4 ACTR10 ACTR10 PRNP PRNP RCHY1 RCHY1 HECTD2 HECTD2 HSPA13 HSPA13 UBC UBC CCDC92 CCDC92 CPNE8 CPNE8 EXOC6B EXOC6B EXOC6 EXOC6
"HECTD2" - HECT domain containing E3 ubiquitin protein ligase 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HECTD2HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) (776 aa)    
Predicted Functional Partners:
CCDC92
coiled-coil domain containing 92 (331 aa)
            score_image   0.653
CPNE8
copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) (564 aa)
            score_image   0.652
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.609
EXOC6
exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity) (804 aa)
            score_image   0.569
HSPA13
heat shock protein 70kDa family, member 13; Has peptide-independent ATPase activity (471 aa)
        score_image   score_image   0.545
RCHY1
ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity (261 aa)
            score_image   0.537
EXOC6B
exocyst complex component 6B; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (811 aa)
            score_image   0.527
ACTR10
actin-related protein 10 homolog (S. cerevisiae) (417 aa)
        score_image   score_image   0.511
HECTD4
HECT domain containing E3 ubiquitin protein ligase 4 (4272 aa)
            score_image   0.510
PRNP
prion protein (253 aa)
            score_image   0.506
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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