node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR10 | HECTD2 | ENSP00000254286 | ENSP00000298068 | actin-related protein 10 homolog (S. cerevisiae) | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | 0.511 |
ACTR10 | HSPA13 | ENSP00000254286 | ENSP00000285667 | actin-related protein 10 homolog (S. cerevisiae) | heat shock protein 70kDa family, member 13; Has peptide-independent ATPase activity | 0.479 |
ACTR10 | RCHY1 | ENSP00000254286 | ENSP00000321239 | actin-related protein 10 homolog (S. cerevisiae) | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity | 0.533 |
ACTR10 | UBC | ENSP00000254286 | ENSP00000344818 | actin-related protein 10 homolog (S. cerevisiae) | ubiquitin C | 0.819 |
CCDC92 | HECTD2 | ENSP00000238156 | ENSP00000298068 | coiled-coil domain containing 92 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | 0.653 |
CPNE8 | HECTD2 | ENSP00000329748 | ENSP00000298068 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | 0.652 |
CPNE8 | UBC | ENSP00000329748 | ENSP00000344818 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | ubiquitin C | 0.854 |
EXOC6 | HECTD2 | ENSP00000260762 | ENSP00000298068 | exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity) | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | 0.569 |
EXOC6 | UBC | ENSP00000260762 | ENSP00000344818 | exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity) | ubiquitin C | 0.734 |
EXOC6B | HECTD2 | ENSP00000272427 | ENSP00000298068 | exocyst complex component 6B; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | 0.527 |
EXOC6B | UBC | ENSP00000272427 | ENSP00000344818 | exocyst complex component 6B; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | ubiquitin C | 0.734 |
HECTD2 | ACTR10 | ENSP00000298068 | ENSP00000254286 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | actin-related protein 10 homolog (S. cerevisiae) | 0.511 |
HECTD2 | CCDC92 | ENSP00000298068 | ENSP00000238156 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | coiled-coil domain containing 92 | 0.653 |
HECTD2 | CPNE8 | ENSP00000298068 | ENSP00000329748 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | 0.652 |
HECTD2 | EXOC6 | ENSP00000298068 | ENSP00000260762 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity) | 0.569 |
HECTD2 | EXOC6B | ENSP00000298068 | ENSP00000272427 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | exocyst complex component 6B; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | 0.527 |
HECTD2 | HECTD4 | ENSP00000298068 | ENSP00000449784 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | HECT domain containing E3 ubiquitin protein ligase 4 | 0.510 |
HECTD2 | HSPA13 | ENSP00000298068 | ENSP00000285667 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | heat shock protein 70kDa family, member 13; Has peptide-independent ATPase activity | 0.545 |
HECTD2 | PRNP | ENSP00000298068 | ENSP00000368752 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | prion protein | 0.506 |
HECTD2 | RCHY1 | ENSP00000298068 | ENSP00000321239 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity | 0.537 |