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CYTH2 CYTH2 SPAG9 SPAG9 FBXO8 FBXO8 TIAM1 TIAM1 CYTH3 CYTH3 ARF6 ARF6 RAC1 RAC1 PXN PXN ACAP1 ACAP1 RAB11FIP3 RAB11FIP3 GGA3 GGA3
"ARF6" - ADP-ribosylation factor 6 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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ARF6ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension (175 aa)    
Predicted Functional Partners:
CYTH2
cytohesin 2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (399 aa)
        score_image score_image score_image   0.999
SPAG9
sperm associated antigen 9 (1321 aa)
        score_image score_image score_image   0.999
CYTH3
cytohesin 3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP (399 aa)
        score_image score_image score_image   0.996
FBXO8
F-box protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential) (319 aa)
        score_image score_image score_image   0.996
RAB11FIP3
RAB11 family interacting protein 3 (class II) (756 aa)
        score_image score_image score_image   0.996
GGA3
golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (723 aa)
        score_image   score_image   0.995
RAC1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] (211 aa)
      score_image score_image score_image score_image   0.995
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface (740 aa)
        score_image score_image score_image   0.992
PXN
paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion) (591 aa)
          score_image score_image   0.990
TIAM1
T-cell lymphoma invasion and metastasis 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA (1591 aa)
          score_image score_image   0.988
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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