Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | TMEM63C | transmembrane protein 63C (806 aa) | ||||||||||||
Predicted Functional Partners:
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 | CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa) |
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0.669 | ||||||||||
 | C10orf112 | chromosome 10 open reading frame 112 (1486 aa) |
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0.584 | ||||||||||
 | SYCP2L | synaptonemal complex protein 2-like (812 aa) |
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0.580 | ||||||||||
 | C3orf67 | chromosome 3 open reading frame 67 (563 aa) |
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0.519 | ||||||||||
 | OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 (331 aa) |
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0.510 | ||||||||||
 | RNPC3 | RNA-binding region (RNP1, RRM) containing 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA (517 aa) |
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0.508 | ||||||||||
 | SRRM4 | serine/arginine repetitive matrix 4; Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural- specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity) (611 aa) |
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0.504 | ||||||||||
 | CCDC34 | coiled-coil domain containing 34 (373 aa) |
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0.499 | ||||||||||
 | SAMD4B | sterile alpha motif domain containing 4B; Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A (694 aa) |
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0.480 | ||||||||||
 | ALDH18A1 | aldehyde dehydrogenase 18 family, member A1 (795 aa) |
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0.472 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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