node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDR1 | FRMD7 | ENSP00000359563 | ENSP00000298542 | cerebellar degeneration-related protein 1, 34kDa | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | 0.748 |
CDR1 | GPR143 | ENSP00000359563 | ENSP00000417161 | cerebellar degeneration-related protein 1, 34kDa | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | 0.514 |
CDR1 | NYX | ENSP00000359563 | ENSP00000340328 | cerebellar degeneration-related protein 1, 34kDa | nyctalopin | 0.662 |
CDR1 | SLC25A14 | ENSP00000359563 | ENSP00000218197 | cerebellar degeneration-related protein 1, 34kDa | solute carrier family 25 (mitochondrial carrier, brain), member 14; Participates in the mitochondrial proton leak measured in brain mitochondria | 0.727 |
CNGB3 | FRMD7 | ENSP00000316605 | ENSP00000298542 | cyclic nucleotide gated channel beta 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical [...] | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | 0.606 |
CNGB3 | GUCY2D | ENSP00000316605 | ENSP00000254854 | cyclic nucleotide gated channel beta 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical [...] | guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction | 0.625 |
CNGB3 | NYX | ENSP00000316605 | ENSP00000340328 | cyclic nucleotide gated channel beta 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical [...] | nyctalopin | 0.487 |
CRYZL1 | FRMD7 | ENSP00000370966 | ENSP00000298542 | crystallin, zeta (quinone reductase)-like 1 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | 0.743 |
CRYZL1 | GPR143 | ENSP00000370966 | ENSP00000417161 | crystallin, zeta (quinone reductase)-like 1 | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | 0.495 |
CRYZL1 | NDP | ENSP00000370966 | ENSP00000367301 | crystallin, zeta (quinone reductase)-like 1 | Norrie disease (pseudoglioma); Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and pr [...] | 0.755 |
CRYZL1 | NYX | ENSP00000370966 | ENSP00000340328 | crystallin, zeta (quinone reductase)-like 1 | nyctalopin | 0.756 |
FOXR2 | FRMD7 | ENSP00000427329 | ENSP00000298542 | forkhead box R2 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | 0.571 |
FOXR2 | UPF3B | ENSP00000427329 | ENSP00000276201 | forkhead box R2 | UPF3 regulator of nonsense transcripts homolog B (yeast); Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mR [...] | 0.472 |
FRMD7 | CDR1 | ENSP00000298542 | ENSP00000359563 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | cerebellar degeneration-related protein 1, 34kDa | 0.748 |
FRMD7 | CNGB3 | ENSP00000298542 | ENSP00000316605 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | cyclic nucleotide gated channel beta 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical [...] | 0.606 |
FRMD7 | CRYZL1 | ENSP00000298542 | ENSP00000370966 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | crystallin, zeta (quinone reductase)-like 1 | 0.743 |
FRMD7 | FOXR2 | ENSP00000298542 | ENSP00000427329 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | forkhead box R2 | 0.571 |
FRMD7 | GPR143 | ENSP00000298542 | ENSP00000417161 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | 0.688 |
FRMD7 | GUCY2D | ENSP00000298542 | ENSP00000254854 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction | 0.563 |
FRMD7 | NDP | ENSP00000298542 | ENSP00000367301 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | Norrie disease (pseudoglioma); Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and pr [...] | 0.604 |