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GPR143 GPR143 CDR1 CDR1 CRYZL1 CRYZL1 SLC25A14 SLC25A14 NDP NDP NYX NYX FRMD7 FRMD7 FOXR2 FOXR2 GUCY2D GUCY2D CNGB3 CNGB3 UPF3B UPF3B
"FRMD7" - FERM domain containing 7 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
FRMD7FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability (714 aa)    
Predicted Functional Partners:
NYX
nyctalopin (481 aa)
            score_image   0.758
CDR1
cerebellar degeneration-related protein 1, 34kDa (262 aa)
            score_image   0.748
CRYZL1
crystallin, zeta (quinone reductase)-like 1 (349 aa)
            score_image   0.743
GPR143
G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport (404 aa)
            score_image   0.688
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14; Participates in the mitochondrial proton leak measured in brain mitochondria (325 aa)
            score_image   0.687
CNGB3
cyclic nucleotide gated channel beta 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical [...] (809 aa)
            score_image   0.606
NDP
Norrie disease (pseudoglioma); Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and pr [...] (133 aa)
            score_image   0.604
UPF3B
UPF3 regulator of nonsense transcripts homolog B (yeast); Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mR [...] (483 aa)
            score_image   0.587
FOXR2
forkhead box R2 (311 aa)
            score_image   0.571
GUCY2D
guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction (1103 aa)
            score_image   0.563
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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