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VIMP VIMP CLASP2 CLASP2 HID1 HID1 GTSE1 GTSE1 SRPRB SRPRB GRAMD3 GRAMD3 PAFAH1B1 PAFAH1B1 C9orf9 C9orf9 CLMP CLMP KIAA1383 KIAA1383 KIAA1009 KIAA1009
"C9orf9" - chromosome 9 open reading frame 9 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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Experiments
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[Homology]
Score
C9orf9chromosome 9 open reading frame 9 (168 aa)    
Predicted Functional Partners:
GRAMD3
GRAM domain containing 3 (447 aa)
          score_image     0.900
CLASP2
cytoplasmic linker associated protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is re [...] (1514 aa)
          score_image     0.900
SRPRB
signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) (271 aa)
          score_image     0.900
GTSE1
G-2 and S-phase expressed 1 (739 aa)
          score_image     0.900
HID1
HID1 domain containing; May play an important role in the development of cancers in a broad range of tissues (788 aa)
          score_image     0.900
CLMP
CXADR-like membrane protein; May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity (373 aa)
          score_image     0.900
KIAA1383
KIAA1383; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis (1047 aa)
          score_image     0.900
KIAA1009
KIAA1009; Functions in cell division regulating chromosome segregation and mitotic spindle assembly (1403 aa)
          score_image     0.900
VIMP
VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (189 aa)
          score_image     0.900
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] (410 aa)
          score_image     0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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