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STRINGSTRING
ABTB2 ABTB2 KRTAP5-7 KRTAP5-7 RNF121 RNF121 MRPL21 MRPL21 ERC2 ERC2 KRTAP5-10 KRTAP5-10 JAKMIP3 JAKMIP3 DEFB108B DEFB108B FAM86C1 FAM86C1 PTK2 PTK2 TYK2 TYK2
"JAKMIP3" - Janus kinase and microtubule interacting protein 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
JAKMIP3Janus kinase and microtubule interacting protein 3 (844 aa)    
Predicted Functional Partners:
KRTAP5-10
keratin associated protein 5-10; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (202 aa)
            score_image   0.569
ERC2
ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ (957 aa)
            score_image   0.546
KRTAP5-7
keratin associated protein 5-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (165 aa)
            score_image   0.535
RNF121
ring finger protein 121 (327 aa)
            score_image   0.517
FAM86C1
family with sequence similarity 86, member C1 (165 aa)
            score_image   0.509
DEFB108B
defensin, beta 108B; Has antibacterial activity (By similarity) (73 aa)
            score_image   0.480
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) (1025 aa)
            score_image   0.472
PTK2
PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] (1065 aa)
            score_image   0.440
TYK2
tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain (1187 aa)
            score_image   0.440
MRPL21
mitochondrial ribosomal protein L21 (205 aa)
            score_image   0.428
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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