ARHGAP42 protein (Homo sapiens) - STRING network view

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ARHGAP42

Rho GTPase activating protein 42; May act as a GTPase activator (By similarity) (874 aa)

Predicted Functional Partners:

ANKUB1

0.700

PSD4

0.640

RERG

0.525

GCFC1

0.520

TMEM133

0.510

FGD4

0.508

CXorf36

0.483

RAP1GAP2

0.467

NEURL1B

0.448

NEURL

0.448

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKUB1	ARHGAP42	ENSP00000387907	ENSP00000298815	ankyrin repeat and ubiquitin domain containing 1	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	0.700
ARHGAP42	ANKUB1	ENSP00000298815	ENSP00000387907	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	ankyrin repeat and ubiquitin domain containing 1	0.700
ARHGAP42	CXorf36	ENSP00000298815	ENSP00000381086	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	chromosome X open reading frame 36	0.483
ARHGAP42	FGD4	ENSP00000298815	ENSP00000394487	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)	0.508
ARHGAP42	GCFC1	ENSP00000298815	ENSP00000328992	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	GC-rich sequence DNA-binding factor 1	0.520
ARHGAP42	NEURL	ENSP00000298815	ENSP00000358795	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	neuralized homolog (Drosophila); May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway (By similarity)	0.448
ARHGAP42	NEURL1B	ENSP00000298815	ENSP00000358815	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	neuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands	0.448
ARHGAP42	PSD4	ENSP00000298815	ENSP00000245796	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	pleckstrin and Sec7 domain containing 4; Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate	0.640
ARHGAP42	RAP1GAP2	ENSP00000298815	ENSP00000254695	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	RAP1 GTPase activating protein 2; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state	0.467
ARHGAP42	RERG	ENSP00000298815	ENSP00000256953	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	RAS-like, estrogen-regulated, growth inhibitor; Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential	0.525
ARHGAP42	TMEM133	ENSP00000298815	ENSP00000303999	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	transmembrane protein 133	0.510
CXorf36	ARHGAP42	ENSP00000381086	ENSP00000298815	chromosome X open reading frame 36	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	0.483
FGD4	ARHGAP42	ENSP00000394487	ENSP00000298815	FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	0.508
FGD4	PSD4	ENSP00000394487	ENSP00000245796	FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)	pleckstrin and Sec7 domain containing 4; Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate	0.423
GCFC1	ARHGAP42	ENSP00000328992	ENSP00000298815	GC-rich sequence DNA-binding factor 1	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	0.520
NEURL	ARHGAP42	ENSP00000358795	ENSP00000298815	neuralized homolog (Drosophila); May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway (By similarity)	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	0.448
NEURL1B	ARHGAP42	ENSP00000358815	ENSP00000298815	neuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	0.448
PSD4	ARHGAP42	ENSP00000245796	ENSP00000298815	pleckstrin and Sec7 domain containing 4; Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	0.640
PSD4	FGD4	ENSP00000245796	ENSP00000394487	pleckstrin and Sec7 domain containing 4; Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate	FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)	0.423
RAP1GAP2	ARHGAP42	ENSP00000254695	ENSP00000298815	RAP1 GTPase activating protein 2; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state	Rho GTPase activating protein 42; May act as a GTPase activator (By similarity)	0.467

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