LIPC protein (Homo sapiens) - STRING network view

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LIPC

lipase, hepatic; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (499 aa)

Predicted Functional Partners:

APOB

0.984

APOE

0.960

LDLR

0.948

LIPF

0.932

DGKG

0.919

DGKA

0.915

CEL

0.915

DGKB

0.912

PNLIP

0.912

MGLL

0.911

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOB	APOE	ENSP00000233242	ENSP00000252486	apolipoprotein B (including Ag(x) antigen)	apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues	0.997
APOB	LDLR	ENSP00000233242	ENSP00000454071	apolipoprotein B (including Ag(x) antigen)	low density lipoprotein receptor	0.999
APOB	LIPC	ENSP00000233242	ENSP00000299022	apolipoprotein B (including Ag(x) antigen)	lipase, hepatic; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin	0.984
APOB	PNLIP	ENSP00000233242	ENSP00000358223	apolipoprotein B (including Ag(x) antigen)	pancreatic lipase	0.507
APOE	APOB	ENSP00000252486	ENSP00000233242	apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues	apolipoprotein B (including Ag(x) antigen)	0.997
APOE	LDLR	ENSP00000252486	ENSP00000454071	apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues	low density lipoprotein receptor	0.997
APOE	LIPC	ENSP00000252486	ENSP00000299022	apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues	lipase, hepatic; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin	0.960
APOE	PNLIP	ENSP00000252486	ENSP00000358223	apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues	pancreatic lipase	0.472
CEL	DGKA	ENSP00000361151	ENSP00000328405	carboxyl ester lipase (bile salt-stimulated lipase); Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides	diacylglycerol kinase, alpha 80kDa; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity	0.900
CEL	DGKB	ENSP00000361151	ENSP00000382260	carboxyl ester lipase (bile salt-stimulated lipase); Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides	diacylglycerol kinase, beta 90kDa	0.900
CEL	DGKG	ENSP00000361151	ENSP00000265022	carboxyl ester lipase (bile salt-stimulated lipase); Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides	diacylglycerol kinase, gamma 90kDa; Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid	0.903
CEL	LIPC	ENSP00000361151	ENSP00000299022	carboxyl ester lipase (bile salt-stimulated lipase); Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides	lipase, hepatic; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin	0.915
CEL	LIPF	ENSP00000361151	ENSP00000377900	carboxyl ester lipase (bile salt-stimulated lipase); Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides	lipase, gastric	0.916
CEL	MGLL	ENSP00000361151	ENSP00000265052	carboxyl ester lipase (bile salt-stimulated lipase); Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides	monoglyceride lipase; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth	0.911
CEL	PNLIP	ENSP00000361151	ENSP00000358223	carboxyl ester lipase (bile salt-stimulated lipase); Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides	pancreatic lipase	0.979
DGKA	CEL	ENSP00000328405	ENSP00000361151	diacylglycerol kinase, alpha 80kDa; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity	carboxyl ester lipase (bile salt-stimulated lipase); Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides	0.900
DGKA	LIPC	ENSP00000328405	ENSP00000299022	diacylglycerol kinase, alpha 80kDa; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity	lipase, hepatic; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin	0.915
DGKA	LIPF	ENSP00000328405	ENSP00000377900	diacylglycerol kinase, alpha 80kDa; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity	lipase, gastric	0.900
DGKA	PNLIP	ENSP00000328405	ENSP00000358223	diacylglycerol kinase, alpha 80kDa; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity	pancreatic lipase	0.900
DGKB	CEL	ENSP00000382260	ENSP00000361151	diacylglycerol kinase, beta 90kDa	carboxyl ester lipase (bile salt-stimulated lipase); Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides	0.900

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