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FAM71E1 FAM71E1 AHSA1 AHSA1 ZNF286B ZNF286B TOE1 TOE1 TMEM161B TMEM161B TCP11L2 TCP11L2 IQCK IQCK ZNF286 ZNF286 FBXW9 FBXW9 SERINC2 SERINC2 SETD7 SETD7
"TCP11L2" - t-complex 11, testis-specific-like 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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Experiments
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[Homology]
Score
TCP11L2t-complex 11, testis-specific-like 2 (519 aa)    
Predicted Functional Partners:
FBXW9
F-box and WD repeat domain containing 9; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) (458 aa)
      score_image         0.623
TOE1
target of EGR1, member 1 (nuclear); Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1 (510 aa)
            score_image   0.597
FAM71E1
family with sequence similarity 71, member E1 (231 aa)
            score_image   0.568
TMEM161B
transmembrane protein 161B (487 aa)
            score_image   0.512
IQCK
IQ motif containing K (287 aa)
            score_image   0.511
ZNF286
Zinc finger protein 286A; cDNA FLJ55788, highly similar to Zinc finger protein 286 ; May be involved in transcriptional regulation (521 aa)
            score_image   0.488
ZNF286B
zinc finger protein 286B; May be involved in transcriptional regulation (By similarity) (522 aa)
            score_image   0.487
AHSA1
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast); Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking (338 aa)
            score_image   0.487
SERINC2
serine incorporator 2 (464 aa)
      score_image     score_image   0.472
SETD7
SET domain containing (lysine methyltransferase) 7; Histone methyltransferase that specifically monomethylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylat [...] (366 aa)
            score_image   0.469
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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